Document Detail


Pandemic versus epidemic influenza mortality: a pattern of changing age distribution.
MedLine Citation:
PMID:  9652423     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Almost all deaths related to current influenza epidemics occur among the elderly. However, mortality was greatest among the young during the 1918-1919 pandemic. This study compared the age distribution of influenza-related deaths in the United States during this century's three influenza A pandemics with that of the following epidemics. Half of influenza-related deaths during the 1968-1969 influenza A (H3N2) pandemic and large proportions of influenza-related deaths during the 1957-1958 influenza A (H2N2) and the 1918-1919 influenza A (H1N1) pandemics occurred among persons <65 years old. However, this group accounted for decrementally smaller proportions of deaths during the first decade following each pandemic. A model suggested that this mortality pattern may be explained by selective acquisition of protection against fatal illness among younger persons. The large proportion of influenza-related deaths during each pandemic and the following decade among persons <65 years old should be considered in planning for pandemics.
Authors:
L Simonsen; M J Clarke; L B Schonberger; N H Arden; N J Cox; K Fukuda
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  The Journal of infectious diseases     Volume:  178     ISSN:  0022-1899     ISO Abbreviation:  J. Infect. Dis.     Publication Date:  1998 Jul 
Date Detail:
Created Date:  1998-07-27     Completed Date:  1998-07-27     Revised Date:  2005-11-22    
Medline Journal Info:
Nlm Unique ID:  0413675     Medline TA:  J Infect Dis     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  53-60     Citation Subset:  AIM; IM    
Affiliation:
Division of Viral and Rickettsial Diseases, National Center for Infectious Diseases, Centers for Disease Control and Prevention, US Department of Health & Human Services, Atlanta, Georgia 30333, USA. Lonesimon@msn.com
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MeSH Terms
Descriptor/Qualifier:
Adolescent
Adult
Age Distribution
Aged
Child
Child, Preschool
Computer Simulation
Disease Outbreaks*
Humans
Infant
Influenza A virus*
Influenza, Human / epidemiology,  mortality*
Middle Aged
Models, Biological
Seasons
United States / epidemiology

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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