| Pandemic influenza and its implications for transplantation. | |
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MedLine Citation:
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PMID: 16827850 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Influenza viruses are important infections in transplant recipients. They may lead to complications including viral pneumonia, secondary bacterial infections and graft dysfunction. There has been a recent widespread outbreak of highly pathogenic H5N1 avian influenza among domestic poultry and wild birds along with a number of human cases with severe disease and high mortality. Genetic changes in the H5N1 virus may lead to efficient human-to-human transmission, heralding the onset of the next influenza pandemic. Discussed are the implications that such a pandemic may have on transplant patients. Logical inferences can be made from data on influenza in transplant patients and from experience with other respiratory virus outbreaks. In the event of a pandemic, it is likely that transplant patients will have more severe disease and higher mortality as compared to the general population. Vaccination and antiviral strategies may be less effective in this population. Implications for transplant programs in general are also discussed. |
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Authors:
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D Kumar; A Humar |
Publication Detail:
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Type: Journal Article; Review |
Journal Detail:
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Title: American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons Volume: 6 ISSN: 1600-6135 ISO Abbreviation: Am. J. Transplant. Publication Date: 2006 Jul |
Date Detail:
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Created Date: 2006-07-10 Completed Date: 2006-12-07 Revised Date: 2007-02-14 |
Medline Journal Info:
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Nlm Unique ID: 100968638 Medline TA: Am J Transplant Country: Denmark |
Other Details:
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Languages: eng Pagination: 1512-7 Citation Subset: IM |
Affiliation:
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Infectious Diseases and Multi-Organ Transplantation, University of Toronto, Ontario, Canada. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Animals Birds Disease Outbreaks* Humans Influenza A Virus, H5N1 Subtype* Influenza A virus / physiology* Influenza in Birds / epidemiology*, immunology, prevention & control, therapy Influenza, Human / epidemiology*, immunology, prevention & control, therapy Transplantation* / adverse effects |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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