Document Detail

Pancreotone, an inhibitor of pancreatic secretion in extracts of ileal and colonic mucosa.
MedLine Citation:
PMID:  385834     Owner:  NLM     Status:  MEDLINE    
1. Pancreotone is a polypeptide material obtained from ileal and colonic mucosa by extraction with alcohol and subsequent precipitation by bile salts. 2. In anaesthetized cats in inhibits the actions of secretin on the pancreas, and of pancreozymin on the pancreas and gall-bladder. 3. Pancreotone has a less powerful inhibitory action on pentagastrin-stimulated gastric secretion. 4. The actions of pancreotone resemble the inhibitory effects on the pancreas and stomach of intraileal and intracolonic infusions of oleic acid and other substances in cats with the vagal and splanchnic nerves cut. Pancreotone may be the humoral mediator of these inhibitory effects. 5. A possible relationship between the actions of pancreotone and somatostatin on the stomach, and of pancreotone and pancreatic polypeptide on the pancreas, is discussed.
A A Harper; A J Hood; J Mushens; J R Smy
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  The Journal of physiology     Volume:  292     ISSN:  0022-3751     ISO Abbreviation:  J. Physiol. (Lond.)     Publication Date:  1979 Jul 
Date Detail:
Created Date:  1979-12-18     Completed Date:  1979-12-18     Revised Date:  2009-11-18    
Medline Journal Info:
Nlm Unique ID:  0266262     Medline TA:  J Physiol     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  455-67     Citation Subset:  IM    
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MeSH Terms
Colon / analysis*
Depression, Chemical
Dose-Response Relationship, Drug
Gallbladder / drug effects
Gastric Juice / secretion
Gastrointestinal Hormones / pharmacology*
Guinea Pigs
Ileum / analysis*
Intestinal Mucosa / analysis*
Pancreas / drug effects,  secretion*
Pepsin A / secretion
Peptides / isolation & purification,  pharmacology*
Secretory Rate / drug effects
Reg. No./Substance:
0/Gastrointestinal Hormones; 0/Peptides; EC A

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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