| Pancreotone, an inhibitor of pancreatic secretion in extracts of ileal and colonic mucosa. | |
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MedLine Citation:
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PMID: 385834 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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1. Pancreotone is a polypeptide material obtained from ileal and colonic mucosa by extraction with alcohol and subsequent precipitation by bile salts. 2. In anaesthetized cats in inhibits the actions of secretin on the pancreas, and of pancreozymin on the pancreas and gall-bladder. 3. Pancreotone has a less powerful inhibitory action on pentagastrin-stimulated gastric secretion. 4. The actions of pancreotone resemble the inhibitory effects on the pancreas and stomach of intraileal and intracolonic infusions of oleic acid and other substances in cats with the vagal and splanchnic nerves cut. Pancreotone may be the humoral mediator of these inhibitory effects. 5. A possible relationship between the actions of pancreotone and somatostatin on the stomach, and of pancreotone and pancreatic polypeptide on the pancreas, is discussed. |
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Authors:
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A A Harper; A J Hood; J Mushens; J R Smy |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: The Journal of physiology Volume: 292 ISSN: 0022-3751 ISO Abbreviation: J. Physiol. (Lond.) Publication Date: 1979 Jul |
Date Detail:
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Created Date: 1979-12-18 Completed Date: 1979-12-18 Revised Date: 2009-11-18 |
Medline Journal Info:
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Nlm Unique ID: 0266262 Medline TA: J Physiol Country: ENGLAND |
Other Details:
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Languages: eng Pagination: 455-67 Citation Subset: IM |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Cats Colon / analysis* Depression, Chemical Dose-Response Relationship, Drug Gallbladder / drug effects Gastric Juice / secretion Gastrointestinal Hormones / pharmacology* Guinea Pigs Ileum / analysis* Intestinal Mucosa / analysis* Pancreas / drug effects, secretion* Pepsin A / secretion Peptides / isolation & purification, pharmacology* Secretory Rate / drug effects |
| Chemical | |
Reg. No./Substance:
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0/Gastrointestinal Hormones; 0/Peptides; EC 3.4.23.1/Pepsin A |
| Comments/Corrections | |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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