Document Detail

Pancreatoblastoma. A case report with special emphasis on squamoid corpuscles with optically clear nuclei rich in biotin.
MedLine Citation:
PMID:  12920766     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: Pancreatoblastoma (PBL) is a rare neoplasm that generally occurs in the pediatric age group and shows unique histopathology, including squamoid corpuscles that may contain tumor cells with optically clear nuclei (OCN) rich in biotin. In the English-language literature there have been two reports on the cytology of PBL, but neither of them refers to the cytologic features of squamoid corpuscles. CASE: A 3-year-old boy with nausea and general fatigue was referred to our center. Imaging studies showed an approximately 7.5-cm, left-sided abdominal mass and multiple metastases in the lung. The abdominal mass was biopsied, and its histology showed solid cellular nests with occasional acinar differentiation and squamoid corpuscles. Imprint cytology of the biopsied sample displayed cellular epithelial nests with focal acinar structures and foci composed of larger cells with a low nuclear/cytoplasmic ratio. These foci contained a few tumor cells with biotin-rich OCN and were determined to be squamoid corpuscles. CONCLUSION: Detection of occasional squamoid corpuscles with biotin-rich OCN can be useful in making a diagnosis of PBL on cytologic samples.
Yukari Hasegawa; Yuji Ishida; Keisuke Kato; Rieko Ijiri; Tetsumi Miyake; Shigeo Nishimata; Takako Watanabe; Ikuko Namba; Yoko Hayabuchi; Hisato Kigasawa; Yukichi Tanaka
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Publication Detail:
Type:  Case Reports; Journal Article    
Journal Detail:
Title:  Acta cytologica     Volume:  47     ISSN:  0001-5547     ISO Abbreviation:  Acta Cytol.     Publication Date:    2003 Jul-Aug
Date Detail:
Created Date:  2003-08-18     Completed Date:  2003-12-18     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  0370307     Medline TA:  Acta Cytol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  679-84     Citation Subset:  IM    
Division of Clinical Laboratory, Kanagawa Children's Medical Center, Mutsukawa 2-138-4, Minami-ku, Yokohama, 232-8555, Japan.
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MeSH Terms
Biotin / metabolism
Cell Nucleus / metabolism,  pathology
Child, Preschool
Epithelial Cells / metabolism,  pathology*
Inclusion Bodies / pathology
Neoplasms, Germ Cell and Embryonal / metabolism,  pathology*
Pancreas / metabolism,  pathology*
Pancreatic Neoplasms / metabolism,  pathology*
Stem Cells / metabolism,  pathology*
Tumor Markers, Biological
Reg. No./Substance:
0/Tumor Markers, Biological; 58-85-5/Biotin

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