| Pancreatitis in systemic lupus erythematosus: frequency and associated factors - a review of the Hopkins Lupus Cohort. | |
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MedLine Citation:
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PMID: 20032096 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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OBJECTIVE: Pancreatitis is a rare but potentially life-threatening complication of systemic lupus erythematosus (SLE). Vasculitis of the gastrointestinal tract is the most commonly proposed mechanism. We determined the frequency of SLE-related pancreatitis in the Hopkins Lupus Cohort. METHODS: A large prospective cohort of 1811 patients with SLE was reviewed and clinical and laboratory measures of SLE patients who developed pancreatitis were compared to patients who did not develop pancreatitis. RESULTS: Four percent of patients with SLE had pancreatitis due to SLE. The best multivariate model of clinical and laboratory associations included hypertriglyceridemia, psychosis, pleurisy, gastritis, and anemia. CONCLUSION: Hypertriglyceridemia appears to be a strong associate of pancreatitis in SLE, but antiphospholipid antibodies are not. SLE patients with psychosis and pleurisy are at increased risk for pancreatitis. |
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Authors:
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Ashima Makol; Michelle Petri |
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Publication Detail:
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Type: Journal Article; Research Support, N.I.H., Extramural Date: 2009-12-23 |
Journal Detail:
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Title: The Journal of rheumatology Volume: 37 ISSN: 0315-162X ISO Abbreviation: J. Rheumatol. Publication Date: 2010 Feb |
Date Detail:
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Created Date: 2010-02-11 Completed Date: 2010-05-03 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 7501984 Medline TA: J Rheumatol Country: Canada |
Other Details:
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Languages: eng Pagination: 341-5 Citation Subset: IM |
Affiliation:
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Hopkins Lupus Center, Division of Rheumatology, Department of Internal Medicine, Johns Hopkins University, Baltimore, Maryland 21205, USA. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adult Antibodies, Antiphospholipid Cohort Studies Female Humans Hypertriglyceridemia / complications Lupus Erythematosus, Systemic / complications*, epidemiology* Male Middle Aged Pancreatitis / epidemiology*, etiology* Pleurisy / complications, epidemiology Prevalence Prospective Studies Psychotic Disorders / complications, epidemiology Risk Factors Severity of Illness Index |
| Grant Support | |
ID/Acronym/Agency:
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AR43727/AR/NIAMS NIH HHS; UL1 RR025005/RR/NCRR NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Antibodies, Antiphospholipid |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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