Document Detail


Pancreatitis in systemic lupus erythematosus: frequency and associated factors - a review of the Hopkins Lupus Cohort.
MedLine Citation:
PMID:  20032096     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
OBJECTIVE: Pancreatitis is a rare but potentially life-threatening complication of systemic lupus erythematosus (SLE). Vasculitis of the gastrointestinal tract is the most commonly proposed mechanism. We determined the frequency of SLE-related pancreatitis in the Hopkins Lupus Cohort. METHODS: A large prospective cohort of 1811 patients with SLE was reviewed and clinical and laboratory measures of SLE patients who developed pancreatitis were compared to patients who did not develop pancreatitis. RESULTS: Four percent of patients with SLE had pancreatitis due to SLE. The best multivariate model of clinical and laboratory associations included hypertriglyceridemia, psychosis, pleurisy, gastritis, and anemia. CONCLUSION: Hypertriglyceridemia appears to be a strong associate of pancreatitis in SLE, but antiphospholipid antibodies are not. SLE patients with psychosis and pleurisy are at increased risk for pancreatitis.
Authors:
Ashima Makol; Michelle Petri
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural     Date:  2009-12-23
Journal Detail:
Title:  The Journal of rheumatology     Volume:  37     ISSN:  0315-162X     ISO Abbreviation:  J. Rheumatol.     Publication Date:  2010 Feb 
Date Detail:
Created Date:  2010-02-11     Completed Date:  2010-05-03     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  7501984     Medline TA:  J Rheumatol     Country:  Canada    
Other Details:
Languages:  eng     Pagination:  341-5     Citation Subset:  IM    
Affiliation:
Hopkins Lupus Center, Division of Rheumatology, Department of Internal Medicine, Johns Hopkins University, Baltimore, Maryland 21205, USA.
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MeSH Terms
Descriptor/Qualifier:
Adult
Antibodies, Antiphospholipid
Cohort Studies
Female
Humans
Hypertriglyceridemia / complications
Lupus Erythematosus, Systemic / complications*,  epidemiology*
Male
Middle Aged
Pancreatitis / epidemiology*,  etiology*
Pleurisy / complications,  epidemiology
Prevalence
Prospective Studies
Psychotic Disorders / complications,  epidemiology
Risk Factors
Severity of Illness Index
Grant Support
ID/Acronym/Agency:
AR43727/AR/NIAMS NIH HHS; UL1 RR025005/RR/NCRR NIH HHS
Chemical
Reg. No./Substance:
0/Antibodies, Antiphospholipid

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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