| Pancreatitis associated protein I (PAP-I) alters adhesion and motility of human melanocytes and melanoma cells. | |
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MedLine Citation:
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PMID: 11231317 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Pancreatitis associated protein I is a secretory stress protein first characterized in pancreas during pancreatitis but also expressed in several tissues including hepatic, gastric, and colon cancer. Its concentration in serum can be significant. The relationship of pancreatitis associated protein I to skin cancers was investigated in normal melanocytes, melanoma tumors, and melanoma cell lines. None of them expressed pancreatitis associated protein I, even after stress induction. Adenovirus-mediated pancreatitis associated protein I expression, however, reduced cell adhesion to laminin-1 and fibronectin with a loss of integrin participation. Pancreatitis associated protein I expression stimulated haptotactic and directed migrations of some melanoma cells, but only directed migration was activated in normal melanocytes. Importantly, directed migration and spreading on fibronectin of the responsive melanoma cells were also enhanced when purified rat pancreatitis associated protein I was added to the culture medium of noninfected cells. This indicates that effects in infected cells were elicited by pancreatitis associated protein I after its secretion. Exogenous pancreatitis associated protein I can therefore modify the adhesion and motility of normal and transformed melanocytes, suggesting a potential interaction with melanoma invasivity. |
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Authors:
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C Valery; S Vasseur; F Sabatier; J L Iovanna; J C Dagorn; J J Grob; P Verrando |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: The Journal of investigative dermatology Volume: 116 ISSN: 0022-202X ISO Abbreviation: J. Invest. Dermatol. Publication Date: 2001 Mar |
Date Detail:
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Created Date: 2001-03-20 Completed Date: 2001-04-12 Revised Date: 2010-02-08 |
Medline Journal Info:
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Nlm Unique ID: 0426720 Medline TA: J Invest Dermatol Country: United States |
Other Details:
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Languages: eng Pagination: 426-33 Citation Subset: IM |
Affiliation:
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Laboratoire d'Investigation des Maladies de la Peau LIMP, Universit? de la M?diterran?e, Marseille, France. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Acute-Phase Proteins
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genetics,
metabolism,
pharmacology* Adenoviridae / genetics Antigens, Neoplasm* Cell Adhesion / drug effects Cell Movement / drug effects* Cells, Cultured Gene Transfer Techniques Humans Lectins, C-Type* Melanocytes / drug effects*, metabolism, physiology* Melanoma / metabolism, pathology, physiopathology* Tumor Markers, Biological* |
| Chemical | |
Reg. No./Substance:
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0/Acute-Phase Proteins; 0/Antigens, Neoplasm; 0/Lectins, C-Type; 0/Tumor Markers, Biological; 0/pancreatitis-associated protein |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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