Document Detail


Pancreatitis: a potential complication of liraglutide?
MedLine Citation:
PMID:  23136352     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
OBJECTIVE: To review the evidence surrounding a potential association between liraglutide and pancreatitis.
DATA SOURCES: A literature search was conducted in MEDLINE (1948-July 12, 2012) and EMBASE (1974-week 27, 2012) using the search terms pancreatitis, liraglutide, and glucagon-like peptide 1/adverse effects. Reference citations from identified publications were reviewed. The manufacturer was contacted and regulatory documents from the Food and Drug Administration website were reviewed for unpublished data related to cases of pancreatitis associated with liraglutide use.
STUDY SELECTION AND DATA EXTRACTION: All identified sources that were published in English were considered for inclusion.
DATA SYNTHESIS: Eleven cases of pancreatitis have been reported in patients taking liraglutide. Seven were from the LEAD (Liraglutide Effect and Action in Diabetes) studies, 1 was reported in the extension of a clinical trial, and 1 was in an unpublished obesity trial. Two were published postmarketing case reports. Nine of the cases reported were diagnosed as acute pancreatitis, while 2 were classified as chronic pancreatitis. The mean age of the patients was 57.5 years and mean body mass index was 33.92 kg/m(2). Six of the 11 cases occurred in male patients. Nine of the patients were white and 1 was African American. In 7 of the cases, onset occurred at liraglutide doses at or above 1.8 mg daily. Common comorbidities included history of pancreatitis, cholelithiasis, and diabetes. One case was fatal.
CONCLUSIONS: Pancreatitis is a potential complication with liraglutide therapy. Liraglutide should be used cautiously in patients at risk of pancreatitis (eg, alcohol abuse, history of pancreatitis, cholelithiasis).
Authors:
Andrea S Franks; Phillip H Lee; Christa M George
Publication Detail:
Type:  Journal Article; Review     Date:  2012-11-07
Journal Detail:
Title:  The Annals of pharmacotherapy     Volume:  46     ISSN:  1542-6270     ISO Abbreviation:  Ann Pharmacother     Publication Date:  2012 Nov 
Date Detail:
Created Date:  2012-11-13     Completed Date:  2013-04-18     Revised Date:  2013-05-13    
Medline Journal Info:
Nlm Unique ID:  9203131     Medline TA:  Ann Pharmacother     Country:  United States    
Other Details:
Languages:  eng     Pagination:  1547-53     Citation Subset:  IM    
Affiliation:
University of Tennessee Health Science Center, College of Pharmacy, Department of Clinical Pharmacy, Knoxville, TN, USA. afranks@uthsc.edu
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MeSH Terms
Descriptor/Qualifier:
Diabetes Mellitus, Type 2 / drug therapy
Glucagon-Like Peptide 1 / adverse effects,  analogs & derivatives*
Humans
Hypoglycemic Agents / adverse effects*
Pancreatitis / chemically induced*
Chemical
Reg. No./Substance:
0/Hypoglycemic Agents; 839I73S42A/liraglutide; 89750-14-1/Glucagon-Like Peptide 1

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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