Document Detail


Pancreaticoduodenectomy following chemoradiotherapy for locally advanced adenocarcinoma of the pancreatic head.
MedLine Citation:
PMID:  23458326     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
OBJECTIVES: The aim of this study was to assess oncological outcomes in patients treated with pancreaticoduodenectomy for advanced pancreatic head adenocarcinoma after preoperative chemoradiotherapy and to compare these with outcomes in patients treated with surgery alone.
METHODS: From 2004 to 2009, patients treated with pancreaticoduodenectomy for pancreatic head adenocarcinoma were included in a retrospective comparative study. Patients with locally advanced adenocarcinoma were treated with preoperative chemoradiotherapy (CRT group) and were compared with those treated with surgery alone (SURG group).
RESULTS: A total of 111 patients were included; these comprised 72 patients in the SURG group and 39 patients in the CRT group. The median follow-up was 21 months. Patients in the CRT group presented with a more advanced tumoral status. Microscopic resection rates were similar in both groups, but nodal status and vascular or lymphatic emboli were lower in the CRT group. At 3 years, the SURG and CRT groups exhibited similar overall (36% and 51%, respectively) and disease-free (35% and 37%, respectively) survival (P = 0.10).
CONCLUSIONS: In patients with advanced pancreatic head adenocarcinoma, a good response after preoperative chemoradiotherapy results in a survival rate similar to that in patients treated with surgery alone in whom the initial prognosis is better.
Authors:
Quentin Denost; Christophe Laurent; Jean-Philippe Adam; Maylis Capdepont; Veronique Vendrely; Denis Collet; Antonio Sa Cunha
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Publication Detail:
Type:  Comparative Study; Journal Article     Date:  2013-01-10
Journal Detail:
Title:  HPB : the official journal of the International Hepato Pancreato Biliary Association     Volume:  15     ISSN:  1477-2574     ISO Abbreviation:  HPB (Oxford)     Publication Date:  2013 Sep 
Date Detail:
Created Date:  2013-08-13     Completed Date:  2014-03-11     Revised Date:  2014-09-02    
Medline Journal Info:
Nlm Unique ID:  100900921     Medline TA:  HPB (Oxford)     Country:  England    
Other Details:
Languages:  eng     Pagination:  716-23     Citation Subset:  IM    
Copyright Information:
© 2013 International Hepato-Pancreato-Biliary Association.
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MeSH Terms
Descriptor/Qualifier:
Adenocarcinoma / mortality,  pathology,  therapy*
Aged
Chemoradiotherapy, Adjuvant* / adverse effects,  mortality
Chi-Square Distribution
Disease-Free Survival
Female
Humans
Kaplan-Meier Estimate
Logistic Models
Lymphatic Metastasis
Male
Middle Aged
Multivariate Analysis
Neoadjuvant Therapy* / adverse effects,  mortality
Neoplasm Invasiveness
Pancreatic Neoplasms / mortality,  pathology,  therapy*
Pancreaticoduodenectomy* / adverse effects,  mortality
Retrospective Studies
Risk Factors
Time Factors
Treatment Outcome
Comments/Corrections

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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