Document Detail


Pancreatic-type hyperamylasemia and hyperlipasemia secondary to ruptured ovarian cyst: a case report and review of the literature.
MedLine Citation:
PMID:  18993019     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
BACKGROUND: Although salivary-type hyperamylasemia is known to occur with ovarian pathologies such as salpingitis and adenocarcinoma, pancreatic-type hyperamylasemia and hyperlipasemia are considered to be highly specific for pancreatitis. OBJECTIVES: To discuss the interpretation of hyperamylasemia in the context of acute abdominal pain, implications for management, and to review the literature relating to non-pancreatic causes of hyperamylasemia and hyperlipasemia. CASE REPORT: We present the case of a 25-year-old woman who presented with an acute abdomen and a markedly elevated pancreatic-type amylase and lipase in whom acute pancreatitis was suspected. Further investigations showed that the underlying pathology was actually a ruptured ovarian cyst causing massive intra-abdominal hemorrhage and necessitating emergency laparotomy. CONCLUSIONS: This case represents an initial report of pancreatic-type hyperamylasemia and hyperlipasemia occurring with ovarian pathology and hemoperitoneum. Although these derangements may have been secondary to peritoneal irritation, this case raises the possibility that ovarian tissue is able to secrete large amounts of pancreatic-type amylase and lipase in addition to salivary-type amylase. Clinicians should be aware that simultaneous elevations of both enzymes are not necessarily pathognomic of acute pancreatitis.
Authors:
Sidhartha Sinha; Hamed Khan; Peter M Timms; Olufemi A Olagbaiye
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Publication Detail:
Type:  Case Reports; Journal Article; Review     Date:  2008-11-07
Journal Detail:
Title:  The Journal of emergency medicine     Volume:  38     ISSN:  0736-4679     ISO Abbreviation:  J Emerg Med     Publication Date:  2010 May 
Date Detail:
Created Date:  2010-05-10     Completed Date:  2010-09-13     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8412174     Medline TA:  J Emerg Med     Country:  United States    
Other Details:
Languages:  eng     Pagination:  463-6     Citation Subset:  IM    
Copyright Information:
Copyright (c) 2010 Elsevier Inc. All rights reserved.
Affiliation:
Southend University Hospital NHS Foundation Trust, Essex, UK.
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MeSH Terms
Descriptor/Qualifier:
Abdomen, Acute / etiology
Adult
Amylases / chemistry
Diagnosis, Differential
Female
Hemorrhage / etiology,  radiography*
Humans
Hyperamylasemia / etiology*
Lipase / blood*
Ovarian Cysts / complications*,  radiography*
Pancreatitis / blood,  diagnosis*
Rupture, Spontaneous / complications,  radiography
Chemical
Reg. No./Substance:
EC 3.1.1.3/Lipase; EC 3.2.1.-/Amylases

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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