Document Detail

Pancreatic tissue oxygenation during secretory stimulation.
MedLine Citation:
PMID:  3953817     Owner:  NLM     Status:  MEDLINE    
Pancreatic acinar tissue O2 tension (PO2) was measured in anesthetized rats using recessed-tip microelectrodes (tip diam 1-2 micron). Pancreatic blood flow was measured using radioactive microspheres. Volume rate of pancreatic secretion, as well as protein concentration, was also measured. Average resting PO2 was 24.8 +/- 1.6 mmHg, with relatively little variation evident within a given pancreas. Bolus intravenous infusion of cholecystokinin octapeptide (CCK-OP, 4 micrograms X kg body wt-1) induced a reduction in tissue PO2 and profoundly increased protein output, while not directly affecting pancreatic blood flow. By contrast, secretin infusion (1.0 CU X kg body wt-1 iv bolus) affected neither tissue PO2 nor blood flow, although secretory rate increased by nearly sevenfold. This difference in PO2 response to the two compounds is interpreted in light of the fact that CCK-OP primarily stimulates acinar cell function, while secretin preferentially activates secretory epithelium. Pancreatic PO2 was found to be linearly related to resting blood flow at flows above 44 ml X min-1 X 100 g-1. No regional differences in blood flow were found in the head, body, and tail of the pancreas.
S L Harper; V H Pitts; D N Granger; P R Kvietys
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Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  The American journal of physiology     Volume:  250     ISSN:  0002-9513     ISO Abbreviation:  Am. J. Physiol.     Publication Date:  1986 Mar 
Date Detail:
Created Date:  1986-04-11     Completed Date:  1986-04-11     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  0370511     Medline TA:  Am J Physiol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  G316-22     Citation Subset:  IM    
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MeSH Terms
Oxygen Consumption*
Pancreas / blood supply,  metabolism*,  secretion
Pancreatic Juice / secretion
Rats, Inbred Strains
Regional Blood Flow
Secretin / pharmacology*
Sincalide / pharmacology*
Stimulation, Chemical
Grant Support
Reg. No./Substance:
1393-25-5/Secretin; 25126-32-3/Sincalide

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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