| Pancreatic tissue oxygenation during secretory stimulation. | |
| | |
MedLine Citation:
|
PMID: 3953817 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
Pancreatic acinar tissue O2 tension (PO2) was measured in anesthetized rats using recessed-tip microelectrodes (tip diam 1-2 micron). Pancreatic blood flow was measured using radioactive microspheres. Volume rate of pancreatic secretion, as well as protein concentration, was also measured. Average resting PO2 was 24.8 +/- 1.6 mmHg, with relatively little variation evident within a given pancreas. Bolus intravenous infusion of cholecystokinin octapeptide (CCK-OP, 4 micrograms X kg body wt-1) induced a reduction in tissue PO2 and profoundly increased protein output, while not directly affecting pancreatic blood flow. By contrast, secretin infusion (1.0 CU X kg body wt-1 iv bolus) affected neither tissue PO2 nor blood flow, although secretory rate increased by nearly sevenfold. This difference in PO2 response to the two compounds is interpreted in light of the fact that CCK-OP primarily stimulates acinar cell function, while secretin preferentially activates secretory epithelium. Pancreatic PO2 was found to be linearly related to resting blood flow at flows above 44 ml X min-1 X 100 g-1. No regional differences in blood flow were found in the head, body, and tail of the pancreas. |
| | |
Authors:
|
S L Harper; V H Pitts; D N Granger; P R Kvietys |
Related Documents
:
|
10650267 - Endoscopic measurement of pancreatic tissue perfusion in patients with chronic pancreat... 6479687 - Pancreatography in chronic pancreatitis: international definitions. 10481117 - Therapy for microcirculatory disorders in severe acute pancreatitis: effectiveness of p... 1797067 - Assessment of pancreatic blood flow with positron emission tomography and oxygen-15 water. 11937287 - A doppler system for dynamic vector velocity maps. 5778787 - Lymphoid cellular responses in the blood after immunization in man. |
Publication Detail:
|
Type: Journal Article; Research Support, U.S. Gov't, P.H.S. |
Journal Detail:
|
Title: The American journal of physiology Volume: 250 ISSN: 0002-9513 ISO Abbreviation: Am. J. Physiol. Publication Date: 1986 Mar |
Date Detail:
|
Created Date: 1986-04-11 Completed Date: 1986-04-11 Revised Date: 2007-11-14 |
Medline Journal Info:
|
Nlm Unique ID: 0370511 Medline TA: Am J Physiol Country: UNITED STATES |
Other Details:
|
Languages: eng Pagination: G316-22 Citation Subset: IM |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Animals Male Oxygen Consumption* Pancreas / blood supply, metabolism*, secretion Pancreatic Juice / secretion Rats Rats, Inbred Strains Regional Blood Flow Secretin / pharmacology* Sincalide / pharmacology* Stimulation, Chemical |
| Grant Support | |
ID/Acronym/Agency:
|
AM-33548/AM/NIADDK NIH HHS; HL-00816/HL/NHLBI NIH HHS; HL-33456/HL/NHLBI NIH HHS |
| Chemical | |
Reg. No./Substance:
|
1393-25-5/Secretin; 25126-32-3/Sincalide |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Enterohepatic circulation of bile acids in pigs: diurnal pattern and effect of a reentrant biliary f...
Next Document: Hepatic processing of cholecystokinin peptides. I. Structural specificity and mechanism of hepatic e...