| Pancreatic response in healthy dogs fed diets of various fat compositions. | |
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MedLine Citation:
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PMID: 19405900 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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OBJECTIVE: To indirectly assess the pancreatic response in healthy dogs that were fed diets of different fat compositions with or without supplemental pancreatic enzymes and medium-chain triglycerides (MCTs). ANIMALS: 10 healthy adult dogs. PROCEDURES: Dogs were fed 4 diets once in random order at 1-week intervals; food was withheld from the dogs for > or = 12 hours prior to the feeding of each diet. Diets A and B contained 16% and 5% crude fat, respectively; diet C was composed of diet A with pancreatic enzymes; and diet D was composed of diet B with pancreatic enzymes and MCTs. Serum canine trypsin-like immunoreactivity (cTLI) and canine pancreatic lipase immunoreactivity (cPLI) concentrations were measured before (0 hours) and at 1 to 2 and 6 hours after feeding. Serum gastrin concentration was measured at 0 hours and at 5 to 10 minutes and 1 to 2 hours after feeding. A gastrin assay validation study was performed to confirm accuracy of test results in dogs. Data were analyzed by use of a repeated-measures general ANOVA. RESULTS: Serum cTLI, cPLI, or gastrin concentrations in the dogs did not differ among the different diets fed, among dogs, or over time. When multiple comparisons were analyzed, diet D caused the least amount of measurable pancreatic response, although this difference was not significant. CONCLUSIONS AND CLINICAL RELEVANCE: Results did not indicate a significant effect of dietary fat content or addition of supplemental MCT oil or pancreatic enzymes in diets on serum cTLI, cPLI, or gastrin concentrations in healthy dogs. |
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Authors:
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Fleur E James; Caroline S Mansfield; Jörg M Steiner; David A Williams; Ian D Robertson |
Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: American journal of veterinary research Volume: 70 ISSN: 0002-9645 ISO Abbreviation: Am. J. Vet. Res. Publication Date: 2009 May |
Date Detail:
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Created Date: 2009-05-01 Completed Date: 2009-06-04 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 0375011 Medline TA: Am J Vet Res Country: United States |
Other Details:
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Languages: eng Pagination: 614-8 Citation Subset: IM |
Affiliation:
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Department of Veterinary Clinical Sciences, Murdoch University, Perth, WA, Australia 6150. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Analysis of Variance Animals Diet / veterinary* Dietary Fats / administration & dosage* Dietary Supplements* Dogs / physiology* Enzymes / administration & dosage Female Gastrins / blood Lipase / blood Male Pancreas / physiology* Random Allocation Reproducibility of Results Triglycerides / administration & dosage* Trypsin / blood |
| Chemical | |
Reg. No./Substance:
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0/Dietary Fats; 0/Enzymes; 0/Gastrins; 0/Triglycerides; EC 3.1.1.3/Lipase; EC 3.4.21.4/Trypsin |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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