Document Detail

Pancreatic polypeptide and splanchnic blood flow in anesthetized rats.
MedLine Citation:
PMID:  8545246     Owner:  NLM     Status:  MEDLINE    
The aim of the study was to evaluate the effects of pancreatic polypeptide (PP) on splanchnic blood flow in anesthetized rats. For this purpose, either PP dissolved in saline (225, 450, or 900 pmol/kg body weight/h) or saline alone was infused at a rate of 2 ml/h for 30 min. Immediately after the infusion the blood flow to the whole pancreas, islets, duodenum, and colon was measured with a microsphere technique. The highest dose of PP caused a small decrease in mean arterial blood pressure. The two lowest doses decreased duodenal blood flow, but did not affect the blood perfusion to the other investigated organs. The highest dose of PP decreased the blood flow to the pancreas, islets, and duodenum, did not affect colonic blood flow. No change in the fraction of whole pancreatic blood flow diverted through the islets could be seen after PP administration. It is concluded that administration of high doses of PP induces a general splanchnic vasoconstriction.
L Jansson; S Efendic
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Peptides     Volume:  16     ISSN:  0196-9781     ISO Abbreviation:  Peptides     Publication Date:  1995  
Date Detail:
Created Date:  1996-02-13     Completed Date:  1996-02-13     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  8008690     Medline TA:  Peptides     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  1253-6     Citation Subset:  IM    
Department of Medical Cell Biology, Uppsala University, Sweden.
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MeSH Terms
Blood Glucose / drug effects
Blood Pressure / drug effects
Body Weight
Dose-Response Relationship, Drug
Hemodynamics / drug effects*
Infusions, Intravenous
Insulin / blood
Islets of Langerhans / blood supply*
Pancreatic Polypeptide / pharmacology*
Rats, Sprague-Dawley
Splanchnic Circulation / drug effects*
Reg. No./Substance:
0/Blood Glucose; 11061-68-0/Insulin; 59763-91-6/Pancreatic Polypeptide

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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