Document Detail


Pancreatic peptide YY in alloxan diabetic mice.
MedLine Citation:
PMID:  7937696     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Peptide YY (PYY) immunoreactive material was detected in the splenic and duodenal portions of the adult mouse pancreas, using immunocytochemical and immunochemical methods. Cells displaying PYY immunoreactivity generally occurred at the islet periphery. Double immunostaining enabled localization of PYY to a major subpopulation of the glucagon cells and to subpopulations of the pancreatic polypeptide (PP) cells and the somatostatin cells. In contrast, no PYY immunoreactivity occurred in the insulin cells. In alloxan-treated hyperglycemic mice, PYY immunoreactive cells were increased in number and distributed throughout the islets, in parallel with the glucagon, PP, and somatostatin cells. Analysis by radioimmunoassay indicated a significant increase in the concentration of pancreatic PYY after alloxan treatment in the splenic portion of the pancreas, but not in the duodenal portion. Pancreatic glucagon concentrations were not significantly changed. It is concluded that the islet content of PYY increases in alloxan diabetes, which might contribute to the accompanying alterations in islet function.
Authors:
G Böttcher; R Ekman; G Lundqvist; B Ahrén; F Sundler
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Pancreas     Volume:  9     ISSN:  0885-3177     ISO Abbreviation:  Pancreas     Publication Date:  1994 Jul 
Date Detail:
Created Date:  1994-11-04     Completed Date:  1994-11-04     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  8608542     Medline TA:  Pancreas     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  469-74     Citation Subset:  IM    
Affiliation:
Department of Medical Cell Research, University of Lund, Sweden.
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MeSH Terms
Descriptor/Qualifier:
Alloxan / pharmacology
Animals
Chromatography, High Pressure Liquid
Diabetes Mellitus, Experimental / chemically induced,  metabolism*
Female
Glucagon / analysis
Immunochemistry
Immunohistochemistry
Mice
Peptide YY
Peptides / analysis*
Radioimmunoassay
Chemical
Reg. No./Substance:
0/Peptides; 106388-42-5/Peptide YY; 50-71-5/Alloxan; 9007-92-5/Glucagon

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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