Document Detail


Pancreatic lipase-related protein 2 but not classical pancreatic lipase hydrolyzes galactolipids.
MedLine Citation:
PMID:  8765145     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The pancreatic lipase family contains three subfamilies, the 'classical' lipases and the pancreatic lipase-related proteins 1 (PLRP1) and 2 (PLRP2). Galactolipids are present in membranes of leaves and vegetables and consist of digalactosyldiacylglycerol (DGalDG) monogalactosyldiacylglycerol (MGalDG) and sulfoquinovosyldiacylglycerol (SQDG). These lipids were incubated with PLRP2 from guinea-pig (GPLRP2) and rat (RPLRP2). In the presence of bile salts DGalDG was efficiently hydrolyzed by GPLRP2 and, although less efficiently, by RPLRP2 to digalactosylmonoacylglycerol (DGalMG), free fatty acids and water-soluble galactose-containing compounds. Also, MGalDG and SQDG were hydrolyzed by GPLRP2 and RPLRP2. These data suggest a possible role of PLRP2 in the digestion of dietary galactolipids.
Authors:
L Andersson; F Carriére; M E Lowe; A Nilsson; R Verger
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Biochimica et biophysica acta     Volume:  1302     ISSN:  0006-3002     ISO Abbreviation:  Biochim. Biophys. Acta     Publication Date:  1996 Aug 
Date Detail:
Created Date:  1996-09-19     Completed Date:  1996-09-19     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  0217513     Medline TA:  Biochim Biophys Acta     Country:  NETHERLANDS    
Other Details:
Languages:  eng     Pagination:  236-40     Citation Subset:  IM    
Affiliation:
Department of Internal Medicine, University of Lund, Sweden.
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MeSH Terms
Descriptor/Qualifier:
Animals
Bile Acids and Salts / pharmacology
Fatty Acids / metabolism
Fatty Acids, Nonesterified / metabolism
Galactolipids
Galactose / metabolism
Glycolipids / metabolism*
Guinea Pigs
Hydrolysis
Kinetics
Lipase / metabolism*
Pancreas / enzymology*
Rats
Recombinant Proteins / metabolism
Grant Support
ID/Acronym/Agency:
DK-33487/DK/NIDDK NIH HHS
Chemical
Reg. No./Substance:
0/Bile Acids and Salts; 0/Fatty Acids; 0/Fatty Acids, Nonesterified; 0/Galactolipids; 0/Glycolipids; 0/Recombinant Proteins; 26566-61-0/Galactose; EC 3.1.1.-/pancreatic lipase related protein 2; EC 3.1.1.3/Lipase

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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