Document Detail

Pancreatic lesions in HIV-infected patients.
MedLine Citation:
PMID:  7811227     Owner:  NLM     Status:  MEDLINE    
The pancreas is frequently involved during HIV infection, especially by disseminated infections or neoplasms. These lesions are generally asymptomatic and are discovered at autopsy. However, hypoglycaemia secondary to massive pancreatic infiltration by a tumour or tuberculous necrosis may occur. The most important cause of pancreatic dysfunction in HIV-infected patients is a drug toxic effect (intravenous pentamidine, didanosine, zalcitabine). Hypoglycaemia, which may or may not be followed by diabetes, can develop during intravenous pentamidine therapy. In cases with increased serum amylase and/or lipase levels, potentially toxic drugs must be promptly discontinued to avoid major pancreatic involvement.
F G Brivet; S H Naveau; G F Lemaigre; J Dormont
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Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  Baillière's clinical endocrinology and metabolism     Volume:  8     ISSN:  0950-351X     ISO Abbreviation:  Baillieres Clin. Endocrinol. Metab.     Publication Date:  1994 Oct 
Date Detail:
Created Date:  1995-01-31     Completed Date:  1995-01-31     Revised Date:  2005-11-16    
Medline Journal Info:
Nlm Unique ID:  8704785     Medline TA:  Baillieres Clin Endocrinol Metab     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  859-77     Citation Subset:  IM; X    
Department of Intrernal Medicine, Hôpital Antoine Béclère, Clamart, France.
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MeSH Terms
AIDS-Related Opportunistic Infections / microbiology
Acute Disease
Didanosine / adverse effects
HIV Infections / complications*,  physiopathology
Pancreas / microbiology,  pathology
Pancreatic Diseases / chemically induced,  etiology*,  microbiology,  pathology
Pancreatitis / etiology
Pentamidine / adverse effects
Trimethoprim-Sulfamethoxazole Combination / adverse effects
Zalcitabine / adverse effects
Reg. No./Substance:
100-33-4/Pentamidine; 69655-05-6/Didanosine; 7481-89-2/Zalcitabine; 8064-90-2/Trimethoprim-Sulfamethoxazole Combination

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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