Document Detail


Pancreatic islet transplantation in the treatment of diabetes mellitus.
MedLine Citation:
PMID:  11472037     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
This chapter reviews current developments and future directions in clinical islet transplantation. With the recent introduction of glucocorticoid-free immunosuppressive therapies and improved methods for islet isolation, the success of the procedure has increased substantially. Challenges ahead include progress with international multicentre trials, development of single donor protocols, progress in clinical tolerance based therapies to lower overall risk of immunosuppression, and ultimately finding an alternative source to provide effective therapy for more patients with diabetes. Recent advances in stem cell biology and xenotransplantation may soon provide this opportunity.
Authors:
A M Shapiro; E A Ryan; J R Lakey
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Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  Best practice & research. Clinical endocrinology & metabolism     Volume:  15     ISSN:  1521-690X     ISO Abbreviation:  Best Pract. Res. Clin. Endocrinol. Metab.     Publication Date:  2001 Jun 
Date Detail:
Created Date:  2001-07-26     Completed Date:  2001-09-13     Revised Date:  2006-10-30    
Medline Journal Info:
Nlm Unique ID:  101120682     Medline TA:  Best Pract Res Clin Endocrinol Metab     Country:  England    
Other Details:
Languages:  eng     Pagination:  241-64     Citation Subset:  IM    
Copyright Information:
Copyright 2001 Harcourt Publishers Ltd.
Affiliation:
Department of Surgery, Faculty of Medicine, University of Alberta, Edmonton, AB, Canada.
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MeSH Terms
Descriptor/Qualifier:
Diabetes Mellitus, Type 1 / surgery*
Humans
Islets of Langerhans Transplantation / methods*

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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