| Pancreatic islet transplantation in the treatment of diabetes mellitus. | |
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MedLine Citation:
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PMID: 11472037 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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This chapter reviews current developments and future directions in clinical islet transplantation. With the recent introduction of glucocorticoid-free immunosuppressive therapies and improved methods for islet isolation, the success of the procedure has increased substantially. Challenges ahead include progress with international multicentre trials, development of single donor protocols, progress in clinical tolerance based therapies to lower overall risk of immunosuppression, and ultimately finding an alternative source to provide effective therapy for more patients with diabetes. Recent advances in stem cell biology and xenotransplantation may soon provide this opportunity. |
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Authors:
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A M Shapiro; E A Ryan; J R Lakey |
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Publication Detail:
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Type: Journal Article; Review |
Journal Detail:
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Title: Best practice & research. Clinical endocrinology & metabolism Volume: 15 ISSN: 1521-690X ISO Abbreviation: Best Pract. Res. Clin. Endocrinol. Metab. Publication Date: 2001 Jun |
Date Detail:
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Created Date: 2001-07-26 Completed Date: 2001-09-13 Revised Date: 2006-10-30 |
Medline Journal Info:
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Nlm Unique ID: 101120682 Medline TA: Best Pract Res Clin Endocrinol Metab Country: England |
Other Details:
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Languages: eng Pagination: 241-64 Citation Subset: IM |
Copyright Information:
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Copyright 2001 Harcourt Publishers Ltd. |
Affiliation:
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Department of Surgery, Faculty of Medicine, University of Alberta, Edmonton, AB, Canada. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Diabetes Mellitus, Type 1
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surgery* Humans Islets of Langerhans Transplantation / methods* |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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