| Pancreatic islet cell carcinoma with gastrin and vasoactive intestinal polypeptide production. | |
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MedLine Citation:
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PMID: 2994597 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The case history of a patient with an islet cell carcinoma, which produced both gastrin and vasoactive intestinal polypeptide (VIP), is presented. Although several examples have been observed of the combined production of these hormones by pancreatic endocrine tumors, few reports have related the clinical details of such cases. Resolution of diarrhea occurred in our patient after institution of nasogastric suction and cimetidine therapy, suggesting that gastric hypersecretion, rather than VIP activity, accounted for this problem. Chemotherapy with streptozotocin and 5-fluorouracil was highly effective in ameliorating clinical symptoms, diminishing serum levels of gastrin and VIP, and greatly reducing the bulk of metastatic disease in this case. |
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Authors:
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T P Barragry; M R Wick; J P Delaney |
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Publication Detail:
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Type: Case Reports; Journal Article |
Journal Detail:
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Title: Archives of surgery (Chicago, Ill. : 1960) Volume: 120 ISSN: 0004-0010 ISO Abbreviation: Arch Surg Publication Date: 1985 Oct |
Date Detail:
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Created Date: 1985-10-16 Completed Date: 1985-10-16 Revised Date: 2006-04-24 |
Medline Journal Info:
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Nlm Unique ID: 9716528 Medline TA: Arch Surg Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 1178-81 Citation Subset: AIM; IM |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adenoma, Islet Cell
/
complications,
drug therapy,
secretion* Antineoplastic Combined Chemotherapy Protocols / therapeutic use Female Fluorouracil / administration & dosage Gastrins / secretion* Humans Middle Aged Pancreatic Neoplasms / complications, drug therapy, secretion* Streptozocin / administration & dosage Vasoactive Intestinal Peptide / secretion* Zollinger-Ellison Syndrome / complications |
| Chemical | |
Reg. No./Substance:
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0/Gastrins; 18883-66-4/Streptozocin; 37221-79-7/Vasoactive Intestinal Peptide; 51-21-8/Fluorouracil |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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