Document Detail

Pancreatic islet cell carcinoma with gastrin and vasoactive intestinal polypeptide production.
MedLine Citation:
PMID:  2994597     Owner:  NLM     Status:  MEDLINE    
The case history of a patient with an islet cell carcinoma, which produced both gastrin and vasoactive intestinal polypeptide (VIP), is presented. Although several examples have been observed of the combined production of these hormones by pancreatic endocrine tumors, few reports have related the clinical details of such cases. Resolution of diarrhea occurred in our patient after institution of nasogastric suction and cimetidine therapy, suggesting that gastric hypersecretion, rather than VIP activity, accounted for this problem. Chemotherapy with streptozotocin and 5-fluorouracil was highly effective in ameliorating clinical symptoms, diminishing serum levels of gastrin and VIP, and greatly reducing the bulk of metastatic disease in this case.
T P Barragry; M R Wick; J P Delaney
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Publication Detail:
Type:  Case Reports; Journal Article    
Journal Detail:
Title:  Archives of surgery (Chicago, Ill. : 1960)     Volume:  120     ISSN:  0004-0010     ISO Abbreviation:  Arch Surg     Publication Date:  1985 Oct 
Date Detail:
Created Date:  1985-10-16     Completed Date:  1985-10-16     Revised Date:  2006-04-24    
Medline Journal Info:
Nlm Unique ID:  9716528     Medline TA:  Arch Surg     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  1178-81     Citation Subset:  AIM; IM    
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MeSH Terms
Adenoma, Islet Cell / complications,  drug therapy,  secretion*
Antineoplastic Combined Chemotherapy Protocols / therapeutic use
Fluorouracil / administration & dosage
Gastrins / secretion*
Middle Aged
Pancreatic Neoplasms / complications,  drug therapy,  secretion*
Streptozocin / administration & dosage
Vasoactive Intestinal Peptide / secretion*
Zollinger-Ellison Syndrome / complications
Reg. No./Substance:
0/Gastrins; 18883-66-4/Streptozocin; 37221-79-7/Vasoactive Intestinal Peptide; 51-21-8/Fluorouracil

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