| Pancreatic islet blood perfusion in the nonobese diabetic mouse: diabetes-prone female mice exhibit a higher blood flow compared with male mice in the prediabetic phase. | |
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MedLine Citation:
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PMID: 9681505 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The present study tested the hypothesis that changes in pancreatic islet blood flow correlate with the difference in diabetes incidence between male and female nonobese diabetic (NOD) mice. The blood flows were determined by a microsphere technique. In animals aged 10 and 14 weeks, the islet blood perfusion was 3-fold higher in female NOD mice compared with that in either age-matched male NOD mice or age- and sex-matched control ICR mice. At 5 weeks of age islet blood flow was similar in all groups. No differences between male and female NOD mice in whole pancreatic, duodenal, ileal, or colonic blood flows were observed at any time point. Administration of a bolus dose of aminoguanidine (a blocker of inducible nitric oxide synthase) to 10-week-old animals selectively and markedly decreased islet blood flow in female NOD mice, whereas islet blood flow in ICR mice and male NOD mice remained unaffected. Aminoguanidine did not affect mean arterial blood pressure or whole pancreatic blood flow in any of the groups. Injection of N(G)-methyl-L-arginine, an unspecific inhibitor of both constitutive and inducible nitric oxide synthase, markedly decreased whole pancreatic and islet blood flow to the same level in both male and female NOD mice. These combined findings suggest that diabetes-prone female NOD mice have an increased islet blood flow, which is mediated by an excessive production of nitric oxide formed by inducible nitric oxide synthase. The islet blood hyperperfusion may augment homing to the pancreatic islets of inflammatory cells and soluble factors involved in beta-cell destruction during the development of insulin-dependent diabetes mellitus in this animal model. The presently observed gender difference in the blood flow response could, therefore, at least partially explain why female NOD mice are more prone to develop hyperglycemia than the males. |
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Authors:
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P O Carlsson; S Sandler; L Jansson |
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Publication Detail:
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Type: Comparative Study; Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Endocrinology Volume: 139 ISSN: 0013-7227 ISO Abbreviation: Endocrinology Publication Date: 1998 Aug |
Date Detail:
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Created Date: 1998-08-13 Completed Date: 1998-08-13 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 0375040 Medline TA: Endocrinology Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 3534-41 Citation Subset: AIM; IM |
Affiliation:
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Department of Medical Cell Biology, Uppsala University, Sweden. per-ola.carlsson@medcellbiol.uu.se |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Aging Animals Blood Flow Velocity / drug effects Blood Glucose / metabolism Blood Pressure / drug effects Colon / blood supply Diabetes Mellitus, Type 1 / pathology, physiopathology* Duodenum / blood supply Enzyme Inhibitors / pharmacology Female Guanidines / pharmacology Ileum / blood supply Insulin / blood Islets of Langerhans / blood supply*, pathology Male Mice Mice, Inbred ICR Mice, Inbred NOD Nitric Oxide Synthase / antagonists & inhibitors Nitric Oxide Synthase Type II Prediabetic State / physiopathology* Sex Characteristics* |
| Chemical | |
Reg. No./Substance:
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0/Blood Glucose; 0/Enzyme Inhibitors; 0/Guanidines; 11061-68-0/Insulin; 79-17-4/pimagedine; EC 1.14.13.39/Nitric Oxide Synthase; EC 1.14.13.39/Nitric Oxide Synthase Type II; EC 1.14.13.39/Nos2 protein, mouse |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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