Document Detail

Pancreatic involvement in patients with Sjögren's syndrome and primary biliary cirrhosis.
MedLine Citation:
PMID:  8568334     Owner:  NLM     Status:  MEDLINE    
Serum pancreatic enzyme activities, exocrine pancreatic function, and pancreatic ductal morphology were evaluated in patients with one or both of Sjögren's syndrome and primary biliary cirrhosis. Ten of 20 patients with Sjögren's syndrome (50%), 6 of 17 patients with primary biliary cirrhosis (35%), and 4 of 11 patients with both diseases (36%) had an elevated level of at least one pancreatic enzyme, including elastase-1, lipase, and trypsin. Diminished excretion of N-benzoyl-L-tyrosyl-para-aminobenzoic acid was observed in 3 of 17 patients with Sjögren's syndrome (18%), 4 of 16 with primary biliary cirrhosis (25%), and none of 7 with both diseases. Endoscopic retrograde pancreatograms demonstrated an abnormal pancreatic ductal configuration in 3 of 11 patients with Sjögren's syndrome (27%), 2 of 9 with primary biliary cirrhosis (22%), and 3 of 4 with both diseases (75%). Only minimal changes in branches of the pancreatic duct were observed in the pancreatogram. Finally, 9-30% of patients with Sjögren's syndrome and/or primary biliary cirrhosis had a mild and intermittent abdominal pain. These findings support the concept of a disease complex, "autoimmune exocrinopathy," in patients with Sjögren's syndrome, primary biliary cirrhosis, and chronic pancreatitis.
I Nishimori; M Morita; J Kino; M Onodera; Y Nakazawa; K Okazaki; Y Yamamoto; Y Yamamoto
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  International journal of pancreatology : official journal of the International Association of Pancreatology     Volume:  17     ISSN:  0169-4197     ISO Abbreviation:  Int. J. Pancreatol.     Publication Date:  1995 Feb 
Date Detail:
Created Date:  1996-03-01     Completed Date:  1996-03-01     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  8703511     Medline TA:  Int J Pancreatol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  47-54     Citation Subset:  IM    
First Department of Internal Medicine, Kochi Medical School, Japan.
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MeSH Terms
4-Aminobenzoic Acid / analogs & derivatives,  diagnostic use
Cholangiopancreatography, Endoscopic Retrograde
Lipase / blood
Liver Cirrhosis, Biliary / physiopathology*,  radiography
Middle Aged
Pancreas / enzymology,  physiopathology*
Pancreatic Elastase / blood
Pancreatic Function Tests
Sjogren's Syndrome / physiopathology*,  radiography
Trypsin / blood
Reg. No./Substance:
150-13-0/4-Aminobenzoic Acid; 37106-97-1/bentiromide; EC; EC Elastase; EC

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