| Pancreatic interstitial pH in human and feline chronic pancreatitis. | |
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MedLine Citation:
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PMID: 7557149 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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BACKGROUND & AIMS: Advanced chronic pancreatitis is associated with a reduction in pancreatic blood flow. To determine the physiological significance of this decrease, pancreatic interstitial pH was measured in a model of obstructive chronic pancreatitis in cats and in patients with chronic pancreatitis. METHODS: In cats, pancreatic interstitial pH and blood flow were measured serially under basal conditions and after secretory stimulation as chronic pancreatitis evolved. Basal pancreatic interstitial pH was also measured in patients undergoing an operation for chronic pancreatitis or periampullary cancer (controls). RESULTS: In normal cats, pancreatic interstitial pH was 7.41 +/- 0.01 and blood flow was 124 mL.min-1.(100 g pancreas-1). With the evolution of chronic pancreatitis, interstitial pH and blood flow progressively decreased to 7.21 +/- 0.04 (P < 0.007) and 75 +/- 11 (P < 0.007), respectively. From 1 to 2 weeks, secretory stimulation reduced pancreatic interstitial pH and blood flow further, but as secretory function was lost, this effect disappeared. In patients with chronic pancreatitis, the interstitial pH was lower (7.02 +/- 0.06) than in controls (7.25 +/- 0.04; P < 0.05). CONCLUSIONS: These observations are consistent with the hypothesis that, in chronic pancreatitis, acidic metabolites associated with pancreatic secretion accumulate within the pancreas, probably because of impaired blood flow. |
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Authors:
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A G Patel; M T Toyama; C Alvarez; T N Nguyen; P U Reber; S W Ashley; H A Reber |
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Publication Detail:
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Type: Journal Article; Research Support, U.S. Gov't, Non-P.H.S. |
Journal Detail:
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Title: Gastroenterology Volume: 109 ISSN: 0016-5085 ISO Abbreviation: Gastroenterology Publication Date: 1995 Nov |
Date Detail:
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Created Date: 1995-11-21 Completed Date: 1995-11-21 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 0374630 Medline TA: Gastroenterology Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 1639-45 Citation Subset: AIM; IM |
Affiliation:
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Department of Surgery, Sepulveda Veterans Administration Medical Center, Los Angeles, California, USA. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adult Aged Animals Cats Chronic Disease Female Humans Hydrogen-Ion Concentration Male Middle Aged Pancreas / blood supply, metabolism* Pancreatitis / metabolism*, physiopathology |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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