Document Detail

Pancreatic hypoperfusion and the production of a myocardial depressant factor in hemorrhagic shock.
MedLine Citation:
PMID:  4835505     Owner:  NLM     Status:  MEDLINE    
Hemorrhagic shock was produced in dogs by bleeding to a systemic blood pressure of 45 mm Hg for 3 hours, followed by reinfusion of the shed blood. A rapid decrease in pancreatic blood flow occurred and pancreatic perfusion remained at 15-25% of control over the entire 3-hour oligemic period. As a consequence of this marked degree of pancreatic hypoperfusion, autolytic changes occurred in pancreatic acinar cell ultrastructure, particularly in the enlarging of lysosomes which developed many vacuoles. Plasma proteolytic indices (e.g., cathepsin D activity and amino nitrogen concentration) markedly increased during shock as well as the activity of a myocardial depressant factor (MDF). MDF was also produced in incubated pancreatic homogenates obtained from nonshocked dogs and in non-incubated homogenates from shocked dogs. MDF activity in the homogenates was closely correlated with amino nitrogen concentration. These data suggest that pancreatic hypoperfusion plays a key role in MDF formation and ultimately in the pathogenesis of circulatory shock. Moreover, MDF activity was found not to be associated either with pentobarbital concentration or the salt content of active fractions of plasma and pancreatic tissue. Ashing of active fractions was very effective in destroying MDF activity. These data are consistent with the earlier findings that indicate MDF to be a peptide having a molecular weight of 500-1,000.
A M Lefer; J A Spath
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Annals of surgery     Volume:  179     ISSN:  0003-4932     ISO Abbreviation:  Ann. Surg.     Publication Date:  1974 Jun 
Date Detail:
Created Date:  1974-08-16     Completed Date:  1974-08-16     Revised Date:  2009-11-18    
Medline Journal Info:
Nlm Unique ID:  0372354     Medline TA:  Ann Surg     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  868-76     Citation Subset:  AIM; IM    
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MeSH Terms
Acid Phosphatase / analysis
Anesthesia, Intravenous
Blood Flow Velocity
Blood Pressure
Blood Transfusion, Autologous
Blood Urea Nitrogen
Heart / physiology
Microscopy, Electron
Molecular Weight
Muscle, Smooth / drug effects
Nitrogen / analysis
Pancreas / analysis,  blood supply*,  metabolism,  pathology,  physiopathology
Pentobarbital / pharmacology
Peptide Biosynthesis*
Peptides / analysis,  blood,  pharmacology
Proteins / metabolism
Regional Blood Flow
Shock, Hemorrhagic / physiopathology*
Reg. No./Substance:
0/Peptides; 0/Proteins; 76-74-4/Pentobarbital; 7727-37-9/Nitrogen; EC Phosphatase

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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