Document Detail


Pancreatic hepatocytes. An in vivo model for cell lineage in pancreas of adult rat.
MedLine Citation:
PMID:  2007367     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Multiple foci of hepatocytes differentiate in the pancreas of adult rats subjected to a copper depletion-repletion regimen. Copper deficiency for seven to nine weeks causes an irreversible depletion of over 80% of the acinar cells in the pancreas. When transferred to a normal diet, these rats exhibit only a minimal and spotty acinar cell recovery. This disruption of tissue organization appears to trigger a profound change in cellular commitment, which leads to hepatocyte differentiation in the "oval cells" in the periductal interstitium and the epithelial cells lining the small pancreatic ductules. Pancreatic hepatocytes express several liver-specific genes including albumin, a2u-globulin, carbamoylphosphate synthetase-I, and urate oxidase. Both carbamoylphosphate synthetase-I and glutamine synthetase, the ammonia-metabolizing enzymes, are expressed by all pancreatic hepatocytes; in liver, these are expressed by different populations of hepatocytes. The magnitude of hepatocyte differentiation in this model should facilitate studies on the molecular events regulating changes in cell lineage or differentiation commitment within the pancreas.
Authors:
J K Reddy; M S Rao; A V Yeldandi; X D Tan; R S Dwivedi
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Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Digestive diseases and sciences     Volume:  36     ISSN:  0163-2116     ISO Abbreviation:  Dig. Dis. Sci.     Publication Date:  1991 Apr 
Date Detail:
Created Date:  1991-05-02     Completed Date:  1991-05-02     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  7902782     Medline TA:  Dig Dis Sci     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  502-9     Citation Subset:  AIM; IM    
Affiliation:
Department of Pathology, Northwestern University Medical School, Chicago, Illinois 60611.
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MeSH Terms
Descriptor/Qualifier:
Animals
Cell Differentiation / physiology
Copper / deficiency
Gene Expression / physiology
Liver / cytology,  enzymology
Pancreas / cytology*,  metabolism
Phenotype
RNA, Messenger / analysis
Rats
Stem Cells / cytology
Grant Support
ID/Acronym/Agency:
DK 37958/DK/NIDDK NIH HHS
Chemical
Reg. No./Substance:
0/RNA, Messenger; 7440-50-8/Copper

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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