Document Detail

Pancreatic function in the reserpinized rabbit--a model for cystic fibrosis. I. Effect of secretin.
MedLine Citation:
PMID:  6173836     Owner:  NLM     Status:  MEDLINE    
Pancreatic juice was collected from rabbits treated with reserpine and from untreated controls. The volume of pancreatic juice secreted, flow rate and the bicarbonate output were all significantly reduced in the treated animals during both spontaneous flow and during secretin-stimulated flow. On the other hand, the total protein concentration, the amylase activity and the calcium concentration of the pancreatic juice were all significantly elevated in the treated animals. The elevation in the total protein concentration appeared to be due to both increased amounts of protein and decreased amounts of water. Of particular interest was that secretin stimulation caused the same % increase in the flow rate and output of pancreatic juice in both control and reserpine treated rabbits. The method by which fluid is secreted by the treated animal, therefore, appeared to be depressed at all times and under all conditions. Decreased volumes of pancreatic juice, a decreased bicarbonate output and increased concentrations of protein and calcium are found in this model and are consistent with clinical findings present in the pancreatic secretions obtained from individuals with cystic fibrosis. Therefore, the similarities between secretions of the reserpine treated rabbit and those observed in the cystic fibrosis patient support its use as an experimental model for investigating the abnormal pancreatic secretions in this disease.
M L Shiffman; M J Gillon; W R Galey
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Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Pediatric research     Volume:  16     ISSN:  0031-3998     ISO Abbreviation:  Pediatr. Res.     Publication Date:  1982 Feb 
Date Detail:
Created Date:  1982-04-12     Completed Date:  1982-04-12     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  0100714     Medline TA:  Pediatr Res     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  104-8     Citation Subset:  IM    
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MeSH Terms
Amylases / metabolism
Bicarbonates / metabolism
Calcium / metabolism
Cystic Fibrosis / chemically induced,  metabolism,  physiopathology*
Pancreatic Juice / metabolism,  secretion*
Proteins / metabolism
Secretin / pharmacology*
Secretory Rate / drug effects
Grant Support
Reg. No./Substance:
0/Bicarbonates; 0/Proteins; 1393-25-5/Secretin; 50-55-5/Reserpine; 7440-70-2/Calcium; EC 3.2.1.-/Amylases

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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