| Pancreatic fibrosis in patients with alcoholic dependence syndrome. | |
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MedLine Citation:
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PMID: 8215822 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Pancreatic fibrosis in patients with alcoholic dependence syndrome was studied histopathologically. In 30 of 41 autopsied patients with alcoholic dependence syndrome, fibrosis was observed despite the absence of clinical pancreatitis. The fibrosis was categorized into three types, according to Martin's classification: intralobular sclerosis in 15 cases, perilobular sclerosis in seven cases, and a mixed intralobular and perilobular sclerosis in the remaining eight cases. The type of the fibrosis was not related to the duration of alcohol abuse. Alcoholic liver cirrhosis was coexistent in 23 of the 30 cases of pancreatic fibrosis. These cases were also divided into categories according to the three types, as follows: intralobular sclerosis in 12 (80%) of 15 cases, perilobular sclerosis in four (57%) of seven cases, and mixed sclerosis in seven (88%) of eight cases. That is, intralobular and mixed sclerosis were frequently coexistent with alcoholic liver cirrhosis. When the pancreases from the 19 subjects with intralobular sclerosis and mixed sclerosis coexistent with liver cirrhosis in alcoholic dependence syndrome were compared with 20 pancreases from patients with nonalcoholic liver cirrhosis, periacinar (or intralobular) fibrosis was found in all cases of the former, but in none of the latter. Hence, it was concluded that periacinar fibrosis occurred as a result of alcohol abuse. Pancreatic fibrosis in patients with alcoholic dependence syndrome was distributed mainly in the intralobular areas and was frequently coexistent with alcoholic liver cirrhosis. |
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Authors:
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K Suda; J Akai; T Nakamura |
Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Archives of pathology & laboratory medicine Volume: 117 ISSN: 0003-9985 ISO Abbreviation: Arch. Pathol. Lab. Med. Publication Date: 1993 Oct |
Date Detail:
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Created Date: 1993-11-02 Completed Date: 1993-11-02 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 7607091 Medline TA: Arch Pathol Lab Med Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 1013-6 Citation Subset: AIM; IM |
Affiliation:
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Department of Pathology, Juntendo University School of Medicine, Tokyo, Japan. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adult Alcoholism / complications* Fibrosis / etiology, pathology Humans Liver Cirrhosis / pathology Liver Cirrhosis, Alcoholic / pathology Male Middle Aged Pancreas / pathology* Pancreatic Diseases / etiology, pathology* |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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