Document Detail


Pancreatic exocrine and gallbladder function during long-term treatment with octreotide (SMS 201-995).
MedLine Citation:
PMID:  2185969     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Since octreotide (SMS 201-995, Sandostatin; Sandoz Pharmaceuticals) is a potent inhibitor of pancreatic exocrine secretion and gallbladder contraction, long-term treatment with this drug may theoretically result in impaired pancreatic function and gallstones. However, we observed excellent pancreatic exocrine function--as assessed by the PABA/PAS test--in acromegalics who received octreotide treatment for more than 6 months. Plasma cholecystokinin showed a significant, although blunted, postprandial response, which exceeded the threshold for gallbladder contraction in healthy controls. Remarkably, postprandial gallbladder contraction was completely abolished for at least 2 h during octreotide treatment. In contrast to other studies, none of 16 acromegalic patients on long-term octreotide treatment developed gallstones. Although the incidence of gallstones in patients on long-term octreotide treatment may be increased, the risk seems to be variable.
Authors:
W P Hopman; P A van Liessum; G F Pieters; A G Smals; A Tangerman; J B Jansen; G Rosenbusch; C B Lamers; P W Kloppenborg
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Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  Digestion     Volume:  45 Suppl 1     ISSN:  0012-2823     ISO Abbreviation:  Digestion     Publication Date:  1990  
Date Detail:
Created Date:  1990-06-14     Completed Date:  1990-06-14     Revised Date:  2009-11-19    
Medline Journal Info:
Nlm Unique ID:  0150472     Medline TA:  Digestion     Country:  SWITZERLAND    
Other Details:
Languages:  eng     Pagination:  72-6     Citation Subset:  IM    
Affiliation:
Division of Gastroenterology, University Hospital Nijmegen, The Netherlands.
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MeSH Terms
Descriptor/Qualifier:
4-Aminobenzoic Acid / urine
Acromegaly / drug therapy*
Aminosalicylic Acid / urine
Cholecystokinin / blood
Gallbladder / drug effects*
Humans
Octreotide / therapeutic use*
Pancreas / drug effects*
Chemical
Reg. No./Substance:
150-13-0/4-Aminobenzoic Acid; 65-49-6/Aminosalicylic Acid; 83150-76-9/Octreotide; 9011-97-6/Cholecystokinin

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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