| Pancreatic elastase 1 in stool: variations within one stool passage and individual changes from day to day. | |
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MedLine Citation:
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PMID: 10689738 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Concentration of fecal pancreatic elastase 1 has been claimed to be a highly sensitive and specific noninvasive test for exocrine pancreatic function. The aim of our study was to investigate variations in elastase concentration within one stool passage and from day to day. For the analysis of the variation of fecal elastase within one stool passage, we utilized 3 different samples collected from 8 patients. Further, we assessed the individual day to day variation of fecal elastase using stools collected on 3 consecutive days from 40 patients. For the determination of pancreatic elastase 1 in stool we used an ELISA kit. We found a relatively considerable variation of fecal elastase concentration within one stool passage (n = 8, mean CV = 22%, range 4.6-83.1%) and from day to day (n = 40; mean CV = 26%, range 2.4-61.1%). Therefore, we recommend routine analysis of more than 1 stool sample collected on different days for fecal elastase and to use a borderline area of +/- 25% of the recommended cut off of 200 micrograms/g stool for the diagnosis of pancreatic insufficiency. |
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Authors:
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A Hamwi; M Veitl; G Maenner; H Vogelsang; T Szekeres |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Wiener klinische Wochenschrift Volume: 112 ISSN: 0043-5325 ISO Abbreviation: Wien. Klin. Wochenschr. Publication Date: 2000 Jan |
Date Detail:
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Created Date: 2000-03-24 Completed Date: 2000-03-24 Revised Date: 2004-11-17 |
Medline Journal Info:
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Nlm Unique ID: 21620870R Medline TA: Wien Klin Wochenschr Country: AUSTRIA |
Other Details:
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Languages: eng Pagination: 32-5 Citation Subset: IM |
Affiliation:
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Department of Laboratory Medicine, Division of Clinical Chemistry, University of Vienna, Austria. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Enzyme-Linked Immunosorbent Assay Exocrine Pancreatic Insufficiency / diagnosis* Feces / chemistry* Humans Pancreatic Elastase / analysis* Pancreatic Function Tests Predictive Value of Tests Reference Values |
| Chemical | |
Reg. No./Substance:
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EC 3.4.21.36/Pancreatic Elastase |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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