Document Detail


Pancreatic elastase 1 in stool: variations within one stool passage and individual changes from day to day.
MedLine Citation:
PMID:  10689738     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Concentration of fecal pancreatic elastase 1 has been claimed to be a highly sensitive and specific noninvasive test for exocrine pancreatic function. The aim of our study was to investigate variations in elastase concentration within one stool passage and from day to day. For the analysis of the variation of fecal elastase within one stool passage, we utilized 3 different samples collected from 8 patients. Further, we assessed the individual day to day variation of fecal elastase using stools collected on 3 consecutive days from 40 patients. For the determination of pancreatic elastase 1 in stool we used an ELISA kit. We found a relatively considerable variation of fecal elastase concentration within one stool passage (n = 8, mean CV = 22%, range 4.6-83.1%) and from day to day (n = 40; mean CV = 26%, range 2.4-61.1%). Therefore, we recommend routine analysis of more than 1 stool sample collected on different days for fecal elastase and to use a borderline area of +/- 25% of the recommended cut off of 200 micrograms/g stool for the diagnosis of pancreatic insufficiency.
Authors:
A Hamwi; M Veitl; G Maenner; H Vogelsang; T Szekeres
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Wiener klinische Wochenschrift     Volume:  112     ISSN:  0043-5325     ISO Abbreviation:  Wien. Klin. Wochenschr.     Publication Date:  2000 Jan 
Date Detail:
Created Date:  2000-03-24     Completed Date:  2000-03-24     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  21620870R     Medline TA:  Wien Klin Wochenschr     Country:  AUSTRIA    
Other Details:
Languages:  eng     Pagination:  32-5     Citation Subset:  IM    
Affiliation:
Department of Laboratory Medicine, Division of Clinical Chemistry, University of Vienna, Austria.
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MeSH Terms
Descriptor/Qualifier:
Enzyme-Linked Immunosorbent Assay
Exocrine Pancreatic Insufficiency / diagnosis*
Feces / chemistry*
Humans
Pancreatic Elastase / analysis*
Pancreatic Function Tests
Predictive Value of Tests
Reference Values
Chemical
Reg. No./Substance:
EC 3.4.21.36/Pancreatic Elastase

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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