Document Detail

Pancreatic duct and microvascular permeability to macromolecules. The relation to acute pancreatitis.
MedLine Citation:
PMID:  3859917     Owner:  NLM     Status:  MEDLINE    
In a model of acute pancreatitis which requires that pancreatic enzymes leak from a permeable duct, we studied the role of intravenous enterokinase (195,000 daltons) in pancreatic enzyme activation. Anesthetized cats were given intravenous 16,16-dimethyl prostaglandin E2 to increase pancreatic blood flow and microvascular permeability. In some animals the permeability of the pancreatic duct was increased by perfusion of the duct with glycodeoxycholic acid (7.5 mM). Endogenous enzyme secretion was stimulated by IV CCK and secretin. Some cats also received enterokinase intravenously. Those animals that received PGE2, glycodeoxycholate, and enterokinase all developed pancreatitis. When any of these agents were not given the pancreases appeared normal. These findings were consistent with the hypothesis that intravenous enterokinase leaked from small pancreatic blood vessels into the pancreatic parenchyma and/or ducts where activation of pancreatic enzymes occurred. The development of pancreatitis appeared to require an increase in both microvascular and ductal permeability.
H A Reber
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Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, Non-P.H.S.    
Journal Detail:
Title:  Scandinavian journal of gastroenterology. Supplement     Volume:  112     ISSN:  0085-5928     ISO Abbreviation:  Scand. J. Gastroenterol. Suppl.     Publication Date:  1985  
Date Detail:
Created Date:  1985-08-12     Completed Date:  1985-08-12     Revised Date:  2008-02-13    
Medline Journal Info:
Nlm Unique ID:  0437034     Medline TA:  Scand J Gastroenterol Suppl     Country:  NORWAY    
Other Details:
Languages:  eng     Pagination:  96-100     Citation Subset:  IM    
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MeSH Terms
16,16-Dimethylprostaglandin E2 / pharmacology
Acute Disease
Capillary Permeability / drug effects
Disease Models, Animal
Enteropeptidase / pharmacology
Glycodeoxycholic Acid / pharmacology
Pancreas / blood supply*
Pancreatic Ducts / physiopathology*
Pancreatitis / blood,  chemically induced,  physiopathology*
Particle Size
Reg. No./Substance:
360-65-6/Glycodeoxycholic Acid; 39746-25-3/16,16-Dimethylprostaglandin E2; EC

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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