| Pancreatic duct and microvascular permeability to macromolecules. The relation to acute pancreatitis. | |
| | |
MedLine Citation:
|
PMID: 3859917 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
In a model of acute pancreatitis which requires that pancreatic enzymes leak from a permeable duct, we studied the role of intravenous enterokinase (195,000 daltons) in pancreatic enzyme activation. Anesthetized cats were given intravenous 16,16-dimethyl prostaglandin E2 to increase pancreatic blood flow and microvascular permeability. In some animals the permeability of the pancreatic duct was increased by perfusion of the duct with glycodeoxycholic acid (7.5 mM). Endogenous enzyme secretion was stimulated by IV CCK and secretin. Some cats also received enterokinase intravenously. Those animals that received PGE2, glycodeoxycholate, and enterokinase all developed pancreatitis. When any of these agents were not given the pancreases appeared normal. These findings were consistent with the hypothesis that intravenous enterokinase leaked from small pancreatic blood vessels into the pancreatic parenchyma and/or ducts where activation of pancreatic enzymes occurred. The development of pancreatitis appeared to require an increase in both microvascular and ductal permeability. |
| | |
Authors:
|
H A Reber |
Related Documents
:
|
2826237 - Effect of dibutyryl cyclic amp and theophylline on lipoprotein lipase secretion by huma... 208367 - Adsorption and activation of pancreatic lipase at interfaces. 17950947 - Enhancing the activity and regioselectivity of lipases for 3'-benzoylation of floxuridi... 9300787 - Interaction of lipoprotein lipase with homogeneous lipid emulsions. 3229457 - Separation and characterization of hepatocytes from immature and adult rats into distin... 22870287 - Enhanced cellulose degradation using cellulase-nanosphere complexes. |
Publication Detail:
|
Type: Journal Article; Research Support, U.S. Gov't, Non-P.H.S. |
Journal Detail:
|
Title: Scandinavian journal of gastroenterology. Supplement Volume: 112 ISSN: 0085-5928 ISO Abbreviation: Scand. J. Gastroenterol. Suppl. Publication Date: 1985 |
Date Detail:
|
Created Date: 1985-08-12 Completed Date: 1985-08-12 Revised Date: 2008-02-13 |
Medline Journal Info:
|
Nlm Unique ID: 0437034 Medline TA: Scand J Gastroenterol Suppl Country: NORWAY |
Other Details:
|
Languages: eng Pagination: 96-100 Citation Subset: IM |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
16,16-Dimethylprostaglandin E2
/
pharmacology Acute Disease Animals Capillary Permeability / drug effects Cats Disease Models, Animal Enteropeptidase / pharmacology Glycodeoxycholic Acid / pharmacology Pancreas / blood supply* Pancreatic Ducts / physiopathology* Pancreatitis / blood, chemically induced, physiopathology* Particle Size Permeability |
| Chemical | |
Reg. No./Substance:
|
360-65-6/Glycodeoxycholic Acid; 39746-25-3/16,16-Dimethylprostaglandin E2; EC 3.4.21.9/Enteropeptidase |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Gastrin modulation of pancreatic growth.
Next Document: Quantitative evaluation of monocyte differentiation by electron microscopy: impairment of differenti...