Document Detail

Pancreatic carcinoma associated with the Leser-Trélat sign.
MedLine Citation:
PMID:  9387039     Owner:  NLM     Status:  MEDLINE    
A case of pancreatic carcinoma associated with the Leser-Trélat sign is reported. A 53-yr-old male had complained of mild epigastric discomfort and back pain accompanied by seborrheic keratoses, which had increased in size and number over the previous 6 mo. A tumor was detected in the head of the pancreas and macroscopically curatively resected. His skin lesions diminished after surgery, but progressed again when the tumor recurred. Immunohistology for EGF showed a low level in the pancreatic carcinoma cells but a higher EGF content was recognized in the hyperkeratinized portions of the seborrheic keratoses. Of 130 underlying malignancies described in the 125 reported patients with the Leser-Trélat sign, neoplasms of the gastrointestinal tract were most common, comprising 47.7% of the total. The present case is the third case showing an association between a pancreatic carcinoma and the Leser-Trélat sign, but the first case for which the tumor of the pancreas was diagnosed in an early stage and resected surgically, as a result of the suggestive nature of this sign.
N Ohashi; N Hidaka
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Publication Detail:
Type:  Case Reports; Journal Article; Review    
Journal Detail:
Title:  International journal of pancreatology : official journal of the International Association of Pancreatology     Volume:  22     ISSN:  0169-4197     ISO Abbreviation:  Int. J. Pancreatol.     Publication Date:  1997 Oct 
Date Detail:
Created Date:  1998-02-03     Completed Date:  1998-02-03     Revised Date:  2005-11-16    
Medline Journal Info:
Nlm Unique ID:  8703511     Medline TA:  Int J Pancreatol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  155-60     Citation Subset:  IM    
Department of Surgery, Matsusaka Chuo Hospital, Mie, Japan.
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MeSH Terms
Adenocarcinoma / chemistry,  complications*,  pathology*,  radiography
Epidermal Growth Factor / analysis
Keratosis, Seborrheic / complications*
Middle Aged
Pancreatic Neoplasms / chemistry,  complications*,  pathology*,  radiography
Tomography, X-Ray Computed
Reg. No./Substance:
62229-50-9/Epidermal Growth Factor

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