| Pancreatic blood flow in experimental acute pancreatitis. | |
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MedLine Citation:
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PMID: 7075432 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The etiology and pathogenesis of acute necrotizing hemorrhagic pancreatitis remain controversial. Recent work has suggested that an early fall in pancreatic blood flow, causing ischemia, may be the initiating factor. Using an established rat model of hemorrhagic pancreatitis and the fractional indicator distribution technique with 86RbCl, pancreatic blood flow and tissue perfusion have been measured at various times in the condition. Six groups of ten rats were studied: control sham operation and pancreatitis groups were sacrificed at 1, 6, and 24 hr. Pancreatic blood flow (% of cardiac output) and perfusion (blood flow/g tissue) were measured. Blood flow was increased by a maximum of 53% at 1 hr (P less than 0.001) and remained elevated for 24 hr, and perfusion was increased by a maximum of 70% (P less than 0.001) at 1 hr and remained elevated at 6 hr. Pancreatic perfusion declines after 6 hr due to increasing gland edema. The results demonstrate a significant increase in pancreatic blood flow and perfusion in experimentally induced acute pancreatitis, suggesting a primary inflammatory response, and refute the ischemic etiological theory. |
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Authors:
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A R Berry; A M Millar; T V Taylor |
Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Digestive diseases and sciences Volume: 27 ISSN: 0163-2116 ISO Abbreviation: Dig. Dis. Sci. Publication Date: 1982 May |
Date Detail:
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Created Date: 1982-07-22 Completed Date: 1982-07-22 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 7902782 Medline TA: Dig Dis Sci Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 444-8 Citation Subset: AIM; IM |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Acute Disease Animals Cardiac Output Hemorrhage / complications, physiopathology Pancreas / blood supply* Pancreatitis / etiology, physiopathology* Radioisotopes / diagnostic use Rats Rats, Inbred Strains Regional Blood Flow Rubidium / diagnostic use |
| Chemical | |
Reg. No./Substance:
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0/Radioisotopes; 7440-17-7/Rubidium |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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