Document Detail


Pancreatic beta-cells: from generation to regeneration.
MedLine Citation:
PMID:  20688184     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The pancreas is composed of two main compartments consisting of endocrine and exocrine tissues. The majority of the organ is exocrine and responsible for the synthesis of digestive enzymes and for their transport via an intricate ductal system into the duodenum. The endocrine tissue represents less than 2% of the organ and is organized into functional units called islets of Langerhans, comprising alpha-, beta-, delta-, epsilon- and PP-cells, producing the hormones glucagon, insulin, somatostatin, ghrelin and pancreatic polypeptide (PP), respectively. Insulin-producing beta-cells play a central role in the control of the glucose homeostasis. Accordingly, absolute or relative deficiency in beta-cells may ultimately lead to type 1 and/or type 2 diabetes, respectively. One major goal of diabetes research is therefore to understand the molecular mechanisms controlling the development of beta-cells during pancreas morphogenesis, but also those underlying the regeneration of adult injured pancreas, and assess their significance for future cell-based therapy. In this review, we will therefore present new insights into beta-cell development with focus on beta-cell regeneration.
Authors:
Patrick Collombat; Xiaobo Xu; Harry Heimberg; Ahmed Mansouri
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Review     Date:  2010-08-03
Journal Detail:
Title:  Seminars in cell & developmental biology     Volume:  21     ISSN:  1096-3634     ISO Abbreviation:  Semin. Cell Dev. Biol.     Publication Date:  2010 Oct 
Date Detail:
Created Date:  2010-11-01     Completed Date:  2010-12-06     Revised Date:  2013-05-29    
Medline Journal Info:
Nlm Unique ID:  9607332     Medline TA:  Semin Cell Dev Biol     Country:  England    
Other Details:
Languages:  eng     Pagination:  838-44     Citation Subset:  IM    
Copyright Information:
Copyright © 2010 Elsevier Ltd. All rights reserved.
Affiliation:
Inserm U636, Diabetes Genetics Team, Nice, France.
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MeSH Terms
Descriptor/Qualifier:
Animals
Cell Proliferation
Humans
Insulin-Secreting Cells / cytology*,  physiology*
Mice
Pancreas / cytology,  embryology
Grant Support
ID/Acronym/Agency:
DK05U19DK072495/DK/NIDDK NIH HHS
Comments/Corrections

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