Document Detail


Pancreatic adenomas in infants and children: current surgical management.
MedLine Citation:
PMID:  215734     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Islet cell adenomas are an important consideration in infants and children with hypoglycemia due to hyperinsulinism. Between 1965 and 1977, 32 patients with hyperinsulinism were seen at the Children's Hospital of Philadelphia. Sixteen of these patients underwent surgery. Eight patients had single pancreatic adenomas, 5 of whom were infants under 1 yr of age. In 3 infants an adenoma was recognized and removed at the time of surgery. In 4 patients a subtotal pancreatectomy was successful in removing the adenoma. One infant is whom the adenoma was not included in the subtotal pancreatectomy died postoperatively with intractable hypoglycemia. Of the 7 patients cured by surgery, 6 are normal and 1 has brain damage due to delay in treatment of hypoglycemia. One child has mild diabetes. A combined medical and surgical protocol has been developed that permits rapid diagnosis of hyperinsulinism and selection of candidates for surgery. Infants under 1 yr of age who fail to respond to diazoxide should be explored. In children whose hyperinsulinism appears beyond 1 yr of age, surgery is indicated, since an adenoma is likely.
Authors:
M Gauderer; C A Stanley; L Baker; H C Bishop
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Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Journal of pediatric surgery     Volume:  13     ISSN:  0022-3468     ISO Abbreviation:  J. Pediatr. Surg.     Publication Date:  1978 Dec 
Date Detail:
Created Date:  1979-03-24     Completed Date:  1979-03-24     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0052631     Medline TA:  J Pediatr Surg     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  591-6     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Adenoma, Islet Cell / complications,  pathology,  surgery*
Child
Child, Preschool
Diazoxide / therapeutic use
Follow-Up Studies
Humans
Hyperinsulinism / diagnosis,  drug therapy,  etiology
Hypoglycemia / etiology
Infant
Infant, Newborn
Male
Pancreatectomy / methods
Pancreatic Neoplasms / complications,  pathology,  surgery*
Chemical
Reg. No./Substance:
364-98-7/Diazoxide

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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