Document Detail


Pancreatic acinar-to-beta cell transdifferentiation in vitro.
MedLine Citation:
PMID:  18508625     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Although accumulating evidence indicates that proliferation of pre-existing beta-cells is the major mechanism of the maintenance of postnatal beta-cell mass, new beta-cells can be generated from non-beta-cells under certain conditions in vitro. We have recently shown directly by Cre/loxP-based cell lineage tracing that adult mouse pancreatic acinar cells can be transdifferentiated into insulin-secreting cells in vitro. These newly made cells secrete insulin in response to glucose and other secretagogues, but their secretory capacity is still low compared to that of native beta-cells. To improve the efficiency of generation of insulin-secreting cells from non-beta cells, it is critical to understand the molecular mechanism of such transdifferentiation. Since pancreatic acinar cells are the most abundant cell type in the pancreas, their utilization as a source of surrogate beta-cells is an intriguing approach to cell replacement therapy for type 1 diabetes. This review focuses on current knowledge of the regeneration of pancreatic beta-cells and transdifferentiation of pancreatic acinar-cells into insulin-secreting cells.
Authors:
Kohtaro Minami; Susumu Seino
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Publication Detail:
Type:  In Vitro; Journal Article; Review     Date:  2008-05-01
Journal Detail:
Title:  Frontiers in bioscience : a journal and virtual library     Volume:  13     ISSN:  1093-4715     ISO Abbreviation:  Front. Biosci.     Publication Date:  2008  
Date Detail:
Created Date:  2008-05-29     Completed Date:  2008-09-19     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9709506     Medline TA:  Front Biosci     Country:  United States    
Other Details:
Languages:  eng     Pagination:  5824-37     Citation Subset:  IM    
Affiliation:
Division of Cellular and Molecular Medicine, Department of Physiology and Cell Biology, Kobe University Graduate School of Medicine, 7-5-1 Kusunoki-cho, Chuo-ku, Kobe 650-0017, Japan. kminami@btctr.kobeu.ac.jp
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MeSH Terms
Descriptor/Qualifier:
Animals
Cell Differentiation / physiology*
Diabetes Mellitus, Experimental / physiopathology
Humans
Insulin / secretion
Insulin-Secreting Cells / cytology*,  physiology,  secretion
Mice
Pancreas / cytology,  embryology,  growth & development
Signal Transduction
Transcription Factors / metabolism
Chemical
Reg. No./Substance:
0/Transcription Factors; 11061-68-0/Insulin

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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