| Pancreatic Autoantibodies, HLA DR and PTPN22 Polymorphisms in First Degree Relatives of Patients with Type 1 Diabetes and Multiethnic Background. | |
| | |
MedLine Citation:
|
PMID: 22068554 Owner: NLM Status: In-Data-Review |
Abstract/OtherAbstract:
|
To evaluate the prevalence of pancreatic auto-antibodies (PAb) as well as its relationship with HLA DR B1 and PTPN22 polymorphisms in first degree relatives (FDR) of Brazilian patients with Type 1 diabetes (T1D) and multiethnic background.FDR of patients with T1D were interviewed and blood was sampled for PAb measurement, HLA DRB1 and PTPN22 genotyping. Genotyping was also performed in index cases.In FDR (n=78), 16.7% presented at least one PAb. These individuals had a higher prevalence of HLA DRB1* 03 than others (p=0.03), without differences in PTPN22 genotyping. While the genetic profile was similar in FDR with PAb and their index cases, those without PAb had a lower frequency of HLA DR B1 * 03 than their correspondent patients (p=0.009).In this multiethnic population, a significant proportion of FDR of T1D patients had PAb, which was associated with HLA DR B1 * 03 but not with the PTPN22 polymorphism.Type 1 diabetes and relatives: Antibodies, genetics. |
| | |
Authors:
|
B Barone; J R Dantas; M H Almeida; B S Anna-Gomes; M D R Bencke-Gongalves; M S Albernaz; M R Rodrigues; L Zajdenverg; R Kupfer; A Milech; M Rodacki; J E P Oliveira |
Related Documents
:
|
15991024 - Diabetes-associated hla genotypes affect birthweight in the general population. 12637984 - Signs of beta-cell autoimmunity and hla-defined diabetes susceptibility in the finnish ... 3935724 - No interaction between hla and immunoglobulin igg heavy chain allotypes in early onset ... 19097764 - Molecular interactions in human nail plate analysed by dielectric spectroscopy. 11981264 - Obesity and renal disease. 18432444 - Estimation of energy expenditure in a work environment: comparison of accelerometry and... |
Publication Detail:
|
Type: Journal Article Date: 2011-11-08 |
Journal Detail:
|
Title: Experimental and clinical endocrinology & diabetes : official journal, German Society of Endocrinology [and] German Diabetes Association Volume: 119 ISSN: 1439-3646 ISO Abbreviation: Exp. Clin. Endocrinol. Diabetes Publication Date: 2011 Nov |
Date Detail:
|
Created Date: 2011-11-09 Completed Date: - Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 9505926 Medline TA: Exp Clin Endocrinol Diabetes Country: Germany |
Other Details:
|
Languages: eng Pagination: 618-20 Citation Subset: IM |
Copyright Information:
|
© J. A. Barth Verlag in George Thieme Verlag KG Stuttgart · New York. |
Affiliation:
|
Universidade Federal do Rio de Janeiro (UFRJ). |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
|
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Low-level subchronic arsenic exposure from prenatal developmental stages to adult life results in an...
Next Document: Association of Autonomously Functioning Thyroid Nodules with Hashimoto's Thyroiditis: Study on A Lar...