| Pancreatic adenocarcinoma: variability of diffusion-weighted MR imaging findings. | |
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MedLine Citation:
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PMID: 22623694 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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PURPOSE: To compare the apparent diffusion coefficients (ADCs) of pancreatic adenocarcinomas that appear hyperintense with clearly defined borders (clear hyperintense) with those that do not show clear hyperintense borders on diffusion-weighted magnetic resonance (MR) images. MATERIALS AND METHODS: Institutional review board approval was obtained and informed consent was waived. Eighty patients with histologically confirmed pancreatic adenocarcinoma (mean tumor size, 32 mm) underwent fat-suppressed single-shot echo-planar 3.0-T diffusion-weighted MR imaging with diffusion gradients (b = 1000 sec/mm(2)). ADC values of the pancreatic adenocarcinomas (n = 80) and proximal (n = 51) and distal (n = 70) pancreas were compared by using the Friedman test, followed by the Wilcoxon signed-rank test, and the difference in serum amylase levels between pancreatic adenocarcinomas with and without clear hyperintensity was evaluated by using the x(2) test. RESULTS: In 38 of 80 patients, pancreatic adenocarcinomas showed clear hyperintensity relative to the surrounding pancreas; 26 were hyperintense with unclear distal borders; 12, isointense; and four, hypointense. In all patients, the mean ADC (± standard deviation) of the tumors (1.16 × 10(-3) mm(2)/sec ± 0.22) was significantly lower than those of the proximal pancreas (1.33 × 10(-3) mm(2)/sec ± 0.16, P < .001) and the distal pancreatic parenchyma (1.24 × 10(-3) mm(2)/sec ± 0.23, P = .004). No significant difference in ADC was seen between the pancreatic adenocarcinomas without clear hyperintensity and the distal pancreas. The frequency of serum amylase levels greater than 120 U/L (2.00 μkat/L) was significantly higher than in those with clear hyperintense pancreatic adenocarcinomas (P < .001). CONCLUSION: Diffusion-weighted MR imaging was not useful for delineating 47% of pancreatic adenocarcinomas, because of hyperintensity of the pancreatic parenchyma distal to the cancer. |
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Authors:
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Yoshihiko Fukukura; Koji Takumi; Kiyohisa Kamimura; Toshikazu Shindo; Yuichi Kumagae; Akihiro Tateyama; Masayuki Nakajo |
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Publication Detail:
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Type: Comparative Study; Journal Article |
Journal Detail:
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Title: Radiology Volume: 263 ISSN: 1527-1315 ISO Abbreviation: Radiology Publication Date: 2012 Jun |
Date Detail:
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Created Date: 2012-05-24 Completed Date: 2012-08-13 Revised Date: 2012-10-25 |
Medline Journal Info:
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Nlm Unique ID: 0401260 Medline TA: Radiology Country: United States |
Other Details:
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Languages: eng Pagination: 732-40 Citation Subset: AIM; IM |
Affiliation:
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Department of Radiology, Kagoshima University Graduate School of Medical and Dental Sciences, 8-35-1 Sakuragaoka, Kagoshima 890-8544, Japan. fukukura@m.kufm.kagoshima-u.ac.jp |
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| MeSH Terms | |
Descriptor/Qualifier:
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Adenocarcinoma
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diagnosis*,
radiography Adult Aged Aged, 80 and over Chi-Square Distribution Contrast Media / diagnostic use Diffusion Magnetic Resonance Imaging / methods* Female Humans Image Interpretation, Computer-Assisted Iohexol / diagnostic use Iopamidol / diagnostic use Male Middle Aged Pancreatic Neoplasms / diagnosis*, radiography Retrospective Studies Statistics, Nonparametric Tomography, X-Ray Computed / methods |
| Chemical | |
Reg. No./Substance:
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0/Contrast Media; 62883-00-5/Iopamidol; 66108-95-0/Iohexol |
| Comments/Corrections | |
Erratum In:
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Radiology. 2012 Sep;264(3):920 |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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