| Pancreastatin modulates glucose-stimulated insulin secretion from the perfused rat pancreas. | |
| | |
MedLine Citation:
|
PMID: 8876749 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
Pancreastatin is known to be produced in islet B cells and to inhibit insulin secretion. In this study, we examined whether the peptide affects insulin secretion from the perfused rat pancreas during raising or lowering the glucose concentration within the physiological range. We found that synthetic porcine pancreastatin (15 nmol L-1) significantly inhibited the first phase (5 min) of insulin release induced by raising the glucose concentration from 4.2 to 8.3 mmol L-1 (P < 0.05) without affecting the second phase. Furthermore, the fall in insulin secretion induced by lowering the glucose concentration from 8.3 to 5.5 mmol L-1 was significantly exaggerated in presence of pancreastatin during the first 5 min (P < 0.05). In contrast, pancreastatin did not affect the inhibition of insulin secretion induced by either the alpha 2-adrenoceptor agonist, clonidine (2 nmol L-1), or the P1-purinoceptor (A1-subtype) agonist, N6 (+)-phenylisopropyladenosine (D-PIA) (1.65 mumol L-1). In conclusion, our results show that pancreastatin is a modulator of the early changes in insulin secretion after increase or decrease of the glucose concentration within the physiological range. This suggests that pancreastatin is a modulator of glucose-stimulated insulin secretion. |
| | |
Authors:
|
B Ahrén; G Bertrand; M Roye; G Ribes |
Related Documents
:
|
17639599 - High glucose stimulates gro secretion from rat microglia via ros, pkc, and nf-kappab pa... 4914679 - Synthesis and release of proinsulin and insulin by isolated rat islets of langerhans. 3334729 - Protease inhibitors decrease rabbit cartilage degradation after meniscectomy. 21796809 - Effects of glut4 expression on insulin resistance in patients with advanced liver cirrh... 2168179 - Evidence for a role of microfilaments in insulin release from purified beta-cells. 1541239 - Release of amylin from perfused rat pancreas in response to glucose and glucagon. 21674179 - Hyperinsulinaemic hypoglycaemia and diabetes mellitus due to dominant abcc8/kcnj11 muta... 7729789 - Blunted gh response to growth hormone-releasing hormone (ghrh) alone or combined with a... 2391299 - Amyotrophy in young diabetics: clinical profiles. |
Publication Detail:
|
Type: In Vitro; Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
|
Title: Acta physiologica Scandinavica Volume: 158 ISSN: 0001-6772 ISO Abbreviation: Acta Physiol. Scand. Publication Date: 1996 Sep |
Date Detail:
|
Created Date: 1997-01-23 Completed Date: 1997-01-23 Revised Date: 2006-11-15 |
Medline Journal Info:
|
Nlm Unique ID: 0370362 Medline TA: Acta Physiol Scand Country: ENGLAND |
Other Details:
|
Languages: eng Pagination: 63-70 Citation Subset: IM |
Affiliation:
|
Department of Medicine, Lund University, Malmö, Sweden. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Adrenergic alpha-Agonists
/
pharmacology Animals Blood Glucose / metabolism Clonidine / pharmacology Glucose / pharmacology* Insulin / secretion* Male Pancreas / drug effects, secretion* Pancreatic Hormones / antagonists & inhibitors, pharmacology* Phenylisopropyladenosine / pharmacology Rats Rats, Wistar Receptors, Purinergic P1 / antagonists & inhibitors |
| Chemical | |
Reg. No./Substance:
|
0/Adrenergic alpha-Agonists; 0/Blood Glucose; 0/Pancreatic Hormones; 0/Receptors, Purinergic P1; 106477-83-2/pancreastatin; 11061-68-0/Insulin; 29193-86-0/Phenylisopropyladenosine; 4205-90-7/Clonidine; 50-99-7/Glucose |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Characteristics of fasting and fed myoelectric activity in rat small intestine: evaluation by comput...
Next Document: Perchlorate is hypoglycaemic by amplifying glucose-stimulated insulin secretion in mice.