Document Detail

Pancreas specification: a budding question.
MedLine Citation:
PMID:  12888014     Owner:  NLM     Status:  MEDLINE    
Much recent investigation has been carried out into the mechanisms by which the pancreas is specified from the early endoderm. Recent advances have highlighted important roles for retinoic acid and bone morphogenetic protein signalling in patterning the endoderm at late gastrulation. Subsequently, interactions with the endothelium of the aorta in the dorsal pancreas domain and lateral plate mesoderm in the ventral pancreas domain are the source of essential pancreas-inductive signals. Additionally, the transcription factor Ptf1a has been demonstrated to have a previously unappreciated role in distinguishing pancreas from surrounding duodenal fates.
Maya Kumar; Doug Melton
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Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, P.H.S.; Review    
Journal Detail:
Title:  Current opinion in genetics & development     Volume:  13     ISSN:  0959-437X     ISO Abbreviation:  Curr. Opin. Genet. Dev.     Publication Date:  2003 Aug 
Date Detail:
Created Date:  2003-07-30     Completed Date:  2004-03-17     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  9111375     Medline TA:  Curr Opin Genet Dev     Country:  England    
Other Details:
Languages:  eng     Pagination:  401-7     Citation Subset:  IM    
Howard Hughes Medical Institute, Department of Molecular and Cellular Biology, Harvard University, Cambridge, Massachusetts 02138, USA.
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MeSH Terms
Body Patterning*
Bone Morphogenetic Proteins / metabolism
Embryonic Induction / physiology*
Endoderm / physiology*
Mesoderm / metabolism
Pancreas / anatomy & histology,  embryology*
Signal Transduction / physiology*
Transcription Factors / metabolism
Tretinoin / metabolism
Reg. No./Substance:
0/Bone Morphogenetic Proteins; 0/Transcription Factors; 302-79-4/Tretinoin

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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