Document Detail


Panaxynol induces neurite outgrowth in PC12D cells via cAMP- and MAP kinase-dependent mechanisms.
MedLine Citation:
PMID:  16219303     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Panaxynol, a polyacetylene ((3R)-heptadeca-1,9-diene-4,6-diyn-3-ol; syn. falcarinol), was isolated from the lipophilic fractions of Panax notoginseng, a Chinese traditional medicinal plant. In the present study, we reported the neurotrophic effects of panaxynol on PC12D cells and mechanism involved in neurite outgrowth of the cells. Panaxynol could morphologically promote neurite outgrowth in PC12D cells, concentration-dependently reduce cell division and up-regulate molecular marker (MAP1B) expression in PC12D cells. Panaxynol induces the elevation of intracellular cAMP in PC12D cells. The neurite outgrowth in PC12D cells induced by panaxynol could be inhibited by the protein kinase A inhibitor RpcAMPS and by MAP kinase kinase 1/2 inhibitor U0126. These observations reveal that panaxynol could induce the differentiation of PC12D cells in a process similar to but distinct from that of NGF and the panaxynol's effects were via cAMP- and MAP kinase-dependent mechanisms.
Authors:
Ze-Jian Wang; Bao-Ming Nie; Hong-Zhuan Chen; Yang Lu
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Publication Detail:
Type:  Journal Article     Date:  2005-10-10
Journal Detail:
Title:  Chemico-biological interactions     Volume:  159     ISSN:  0009-2797     ISO Abbreviation:  Chem. Biol. Interact.     Publication Date:  2006 Jan 
Date Detail:
Created Date:  2005-12-13     Completed Date:  2006-02-21     Revised Date:  2009-11-19    
Medline Journal Info:
Nlm Unique ID:  0227276     Medline TA:  Chem Biol Interact     Country:  Ireland    
Other Details:
Languages:  eng     Pagination:  58-64     Citation Subset:  IM    
Affiliation:
Institute of Pharmaceutical Research, Medical College, Shanghai Jiaotong University, Shanghai 200025, PR China.
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MeSH Terms
Descriptor/Qualifier:
Alkynes / pharmacology*
Animals
Cell Differentiation
Cell Division / drug effects
Cyclic AMP-Dependent Protein Kinases / metabolism*
Diynes
Dose-Response Relationship, Drug
Fatty Alcohols / pharmacology*
Gene Expression Regulation / drug effects
Genistein / pharmacology
Microtubule-Associated Proteins / metabolism
Mitogen-Activated Protein Kinases / metabolism*
Neurites / drug effects*
PC12 Cells
Panax / chemistry
Rats
Chemical
Reg. No./Substance:
0/Alkynes; 0/Diynes; 0/Fatty Alcohols; 0/Microtubule-Associated Proteins; 0/microtubule-associated protein 1B; 21852-80-2/falcarinol; 446-72-0/Genistein; EC 2.7.11.11/Cyclic AMP-Dependent Protein Kinases; EC 2.7.11.24/Mitogen-Activated Protein Kinases

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