| Panaxynol induces neurite outgrowth in PC12D cells via cAMP- and MAP kinase-dependent mechanisms. | |
| | |
MedLine Citation:
|
PMID: 16219303 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
Panaxynol, a polyacetylene ((3R)-heptadeca-1,9-diene-4,6-diyn-3-ol; syn. falcarinol), was isolated from the lipophilic fractions of Panax notoginseng, a Chinese traditional medicinal plant. In the present study, we reported the neurotrophic effects of panaxynol on PC12D cells and mechanism involved in neurite outgrowth of the cells. Panaxynol could morphologically promote neurite outgrowth in PC12D cells, concentration-dependently reduce cell division and up-regulate molecular marker (MAP1B) expression in PC12D cells. Panaxynol induces the elevation of intracellular cAMP in PC12D cells. The neurite outgrowth in PC12D cells induced by panaxynol could be inhibited by the protein kinase A inhibitor RpcAMPS and by MAP kinase kinase 1/2 inhibitor U0126. These observations reveal that panaxynol could induce the differentiation of PC12D cells in a process similar to but distinct from that of NGF and the panaxynol's effects were via cAMP- and MAP kinase-dependent mechanisms. |
| | |
Authors:
|
Ze-Jian Wang; Bao-Ming Nie; Hong-Zhuan Chen; Yang Lu |
Related Documents
:
|
21467633 - Transforming growth factor β1 promotes migration of human periodontal ligament cells t... 12424733 - Role of c-jun concentration in neuronal cell death. 8577663 - Isolation and characterization of a feeder-dependent, porcine trophectoderm cell line o... |
Publication Detail:
|
Type: Journal Article Date: 2005-10-10 |
Journal Detail:
|
Title: Chemico-biological interactions Volume: 159 ISSN: 0009-2797 ISO Abbreviation: Chem. Biol. Interact. Publication Date: 2006 Jan |
Date Detail:
|
Created Date: 2005-12-13 Completed Date: 2006-02-21 Revised Date: 2009-11-19 |
Medline Journal Info:
|
Nlm Unique ID: 0227276 Medline TA: Chem Biol Interact Country: Ireland |
Other Details:
|
Languages: eng Pagination: 58-64 Citation Subset: IM |
Affiliation:
|
Institute of Pharmaceutical Research, Medical College, Shanghai Jiaotong University, Shanghai 200025, PR China. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Alkynes
/
pharmacology* Animals Cell Differentiation Cell Division / drug effects Cyclic AMP-Dependent Protein Kinases / metabolism* Diynes Dose-Response Relationship, Drug Fatty Alcohols / pharmacology* Gene Expression Regulation / drug effects Genistein / pharmacology Microtubule-Associated Proteins / metabolism Mitogen-Activated Protein Kinases / metabolism* Neurites / drug effects* PC12 Cells Panax / chemistry Rats |
| Chemical | |
Reg. No./Substance:
|
0/Alkynes; 0/Diynes; 0/Fatty Alcohols; 0/Microtubule-Associated Proteins; 0/microtubule-associated protein 1B; 21852-80-2/falcarinol; 446-72-0/Genistein; EC 2.7.11.11/Cyclic AMP-Dependent Protein Kinases; EC 2.7.11.24/Mitogen-Activated Protein Kinases |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Cardiac and peripheral actions of growth hormone and its releasing peptides: relevance for the treat...
Next Document: 1,2-Dimyristoyl-sn-glycero-3-phosphoglycerol (DMPG) monolayers: influence of temperature, pH, ionic ...