| Pamidronic acid and Paget's disease: new indication. Short-course treatment. | |
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MedLine Citation:
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PMID: 11503825 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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(1) Pamidronic acid, a diphosphonate, is now approved for intravenous treatment of Paget's disease in France. Treatment is given over two to three days, in hospital, and can be repeated six months later. (2) The clinical file contains only non comparative trial data suggesting that a total dose of 180-210 mg has a clinical benefit in most patients and tends to normalise biochemical criteria thought to reflect disease progression. (3) Because no comparative trials have been done, there is no way of knowing whether a short course of intravenous pamidronic acid is any more or less effective that long-term oral etidronic acid or tiludronic acid therapy. However, in the non comparative trials a number of patients who had become resistant to oral diphosphonate therapy had a clinical and/or biochemical response to intravenous pamidronic acid. (4) While intravenous pamidronic acid is well tolerated overall, the precise incidence of its adverse effects on bone (transient increase in pain, osteomalacia) and the eyes (uveitis) is not known. |
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Authors:
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Prescrire international Volume: 8 ISSN: 1167-7422 ISO Abbreviation: Prescrire Int Publication Date: 1999 Aug |
Date Detail:
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Created Date: 2001-03-29 Completed Date: 2001-03-29 Revised Date: 2004-11-17 |
Medline Journal Info:
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Nlm Unique ID: 9439295 Medline TA: Prescrire Int Country: FRANCE |
Other Details:
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Languages: eng Pagination: 104-6 Citation Subset: T |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Diphosphonates*
/
administration & dosage,
adverse effects,
therapeutic use Drug Approval Eye Diseases / chemically induced France Humans Infusions, Intravenous Osteitis Deformans* / drug therapy Time Factors Treatment Outcome |
| Chemical | |
Reg. No./Substance:
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0/Diphosphonates |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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