Document Detail

Pamidronate treatment for hypercalcemia in an infant receiving parenteral nutrition.
MedLine Citation:
PMID:  15303458     Owner:  NLM     Status:  MEDLINE    
A 17-day-old infant who was delivered 8 weeks premature underwent small bowel resection for necrotizing enterocolitis. During treatment with continuous infusions of furosemide and hydrocortisone, his total calcium concentration had increased. The calcium dose in his parenteral nutrition solution was decreased and then finally withheld. At 7 weeks of age and after 10 days of calcium-free parenteral nutrition, pamidronate 3 mg (1.1 mg/kg) in 60 ml of normal saline was infused over 6 hours. The infant's total serum calcium concentration decreased, but then 6 days later it had increased again; pamidronate 2 mg (0.7 mg/kg) in 40 ml of normal saline over 4 hours was administered. The patient demonstrated no signs or symptoms of adverse reactions to pamidronate. His serum calcium concentration returned to normal, and calcium-containing parenteral nutrition was tolerated. The use of pamidronate for treatment of hypercalcemia and chronic conditions that affect normal bone growth is increasing in children. Clinical trials in pediatric patients are necessary to determine how best to use bisphosphonates in this patient population.
Jason J Bryowsky; Mark C Bugnitz; Emily B Hak
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Publication Detail:
Type:  Case Reports; Journal Article    
Journal Detail:
Title:  Pharmacotherapy     Volume:  24     ISSN:  0277-0008     ISO Abbreviation:  Pharmacotherapy     Publication Date:  2004 Jul 
Date Detail:
Created Date:  2004-08-11     Completed Date:  2004-11-04     Revised Date:  2006-03-08    
Medline Journal Info:
Nlm Unique ID:  8111305     Medline TA:  Pharmacotherapy     Country:  United States    
Other Details:
Languages:  eng     Pagination:  939-44     Citation Subset:  IM    
Department of Pharmacy, College of Pharmacy, University of Tennessee Health Science Center Memphis, Tennessee 38163, USA.
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MeSH Terms
Diphosphonates / therapeutic use*
Hypercalcemia / blood,  drug therapy*
Infant, Newborn
Parenteral Nutrition / adverse effects*
Reg. No./Substance:
0/Diphosphonates; 40391-99-9/pamidronate

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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