| Pamidronate results in symptom control of hypertrophic pulmonary osteoarthropathy in cystic fibrosis. | |
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MedLine Citation:
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PMID: 11948079 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Hypertrophic pulmonary osteoarthropathy (HPOA) may complicate the advanced lung disease that is associated with cystic fibrosis, resulting in severe joint pain and early-morning stiffness. Symptoms are usually controlled with the administration of nonsteroidal anti-inflammatory drugs, physiotherapy, and, on occasions, oral corticosteroids. This report describes a case of refractory HPOA with complete remission following the administration of IV pamidronate, which is a potent inhibitor of osteoclastic bone resorption. Symptom relief resulted for up to 3 months, but repeated courses of pamidronate have been required to maintain symptom control. |
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Authors:
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Luke A Garske; Scott C Bell |
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Publication Detail:
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Type: Case Reports; Journal Article |
Journal Detail:
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Title: Chest Volume: 121 ISSN: 0012-3692 ISO Abbreviation: Chest Publication Date: 2002 Apr |
Date Detail:
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Created Date: 2002-04-11 Completed Date: 2002-05-09 Revised Date: 2006-03-08 |
Medline Journal Info:
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Nlm Unique ID: 0231335 Medline TA: Chest Country: United States |
Other Details:
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Languages: eng Pagination: 1363-4 Citation Subset: AIM; IM |
Affiliation:
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Adult Cystic Fibrosis Unit and University of Queensland, The Prince Charles Hospital, Brisbane, Australia. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adult Ankle / radiography Cystic Fibrosis / drug therapy*, radiography Diphosphonates / therapeutic use* Female Humans Infusions, Intravenous Osteoarthropathy, Secondary Hypertrophic / drug therapy*, radiography Osteoclasts / drug effects |
| Chemical | |
Reg. No./Substance:
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0/Diphosphonates; 40391-99-9/pamidronate |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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