Document Detail

Pamidronate results in symptom control of hypertrophic pulmonary osteoarthropathy in cystic fibrosis.
MedLine Citation:
PMID:  11948079     Owner:  NLM     Status:  MEDLINE    
Hypertrophic pulmonary osteoarthropathy (HPOA) may complicate the advanced lung disease that is associated with cystic fibrosis, resulting in severe joint pain and early-morning stiffness. Symptoms are usually controlled with the administration of nonsteroidal anti-inflammatory drugs, physiotherapy, and, on occasions, oral corticosteroids. This report describes a case of refractory HPOA with complete remission following the administration of IV pamidronate, which is a potent inhibitor of osteoclastic bone resorption. Symptom relief resulted for up to 3 months, but repeated courses of pamidronate have been required to maintain symptom control.
Luke A Garske; Scott C Bell
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Publication Detail:
Type:  Case Reports; Journal Article    
Journal Detail:
Title:  Chest     Volume:  121     ISSN:  0012-3692     ISO Abbreviation:  Chest     Publication Date:  2002 Apr 
Date Detail:
Created Date:  2002-04-11     Completed Date:  2002-05-09     Revised Date:  2006-03-08    
Medline Journal Info:
Nlm Unique ID:  0231335     Medline TA:  Chest     Country:  United States    
Other Details:
Languages:  eng     Pagination:  1363-4     Citation Subset:  AIM; IM    
Adult Cystic Fibrosis Unit and University of Queensland, The Prince Charles Hospital, Brisbane, Australia.
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MeSH Terms
Ankle / radiography
Cystic Fibrosis / drug therapy*,  radiography
Diphosphonates / therapeutic use*
Infusions, Intravenous
Osteoarthropathy, Secondary Hypertrophic / drug therapy*,  radiography
Osteoclasts / drug effects
Reg. No./Substance:
0/Diphosphonates; 40391-99-9/pamidronate

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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