Document Detail

Pamidronate infusion improved two cases of intractable seronegative rheumatoid arthritise.
MedLine Citation:
PMID:  22091296     Owner:  NLM     Status:  PubMed-not-MEDLINE    
Pamidronate is a bisphosphonate derivative that can inhibit bone resorption by actions on osteoclasts and increase bone density in spite of treatment with steroids. This drug has the anti-inflammatory effect by increase apoptosis of monocytes. 5-10 percent of rheumatoid arthritis patients is seronegative and may be resistant to conventional disease modifying anti rheumatic drugs (DMARDs). Intravenous (IV) pamidronate can be effective in disease control in seronegative rheumatoid arthritis. We report two cases of seronegative and drug resistant rheumatoid arthritis that favorably responds to pamidronate.
Mansour Salesi; Peyman Mottaghi
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Journal of research in medical sciences : the official journal of Isfahan University of Medical Sciences     Volume:  16     ISSN:  1735-7136     ISO Abbreviation:  J Res Med Sci     Publication Date:  2011 May 
Date Detail:
Created Date:  2011-11-17     Completed Date:  2011-11-23     Revised Date:  2013-05-29    
Medline Journal Info:
Nlm Unique ID:  101235599     Medline TA:  J Res Med Sci     Country:  Iran    
Other Details:
Languages:  eng     Pagination:  703-6     Citation Subset:  -    
Assistant professor, Department of Rheumatology, School of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran.
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