Document Detail


Palytoxin isolated from marine coelenterates. The inhibitory action on (Na,K)-ATPase.
MedLine Citation:
PMID:  6134726     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Palytoxin (PTX), C129H223N3O54, a highly toxic substance isolated from zoanthids of Palythoa tuberculosa, inhibited (Na,K)-ATPase (ATP phosphohydrolase, EC 3.6.1.3) prepared from guinea pig heart and hog cerebral cortex in a dose-dependent manner at concentrations greater than 10(-8) M. In the presence of Na (100 mM) and K (20 mM), PTX showed potency nearly equal to that of ouabain. When the ATPase was activated by the various Na concentrations at a constant K concentration, both PTX and ouabain inhibited the ATPase activity noncompetitively. On the other hand, when K concentration was changed at a constant Na concentration, PTX caused a competitive inhibition in all ranges of K concentrations employed, whereas ouabain caused a competitive inhibition at low concentrations and a noncompetitive inhibition at high concentrations.
Authors:
Y Ishida; K Takagi; M Takahashi; N Satake; S Shibata
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  The Journal of biological chemistry     Volume:  258     ISSN:  0021-9258     ISO Abbreviation:  J. Biol. Chem.     Publication Date:  1983 Jul 
Date Detail:
Created Date:  1983-08-17     Completed Date:  1983-08-17     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  2985121R     Medline TA:  J Biol Chem     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  7900-2     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Acrylamides*
Animals
Cerebral Cortex / enzymology*
Cnidarian Venoms / isolation & purification,  pharmacology*
Guinea Pigs
Kinetics
Myocardium / enzymology*
Ouabain / pharmacology
Sodium-Potassium-Exchanging ATPase / antagonists & inhibitors*
Swine
Chemical
Reg. No./Substance:
0/Acrylamides; 0/Cnidarian Venoms; 11077-03-5/palytoxin; 630-60-4/Ouabain; EC 3.6.3.9/Sodium-Potassium-Exchanging ATPase

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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