Document Detail

Palmitoylethanolamide versus a nonsteroidal anti-inflammatory drug in the treatment of temporomandibular joint inflammatory pain.
MedLine Citation:
PMID:  22558609     Owner:  NLM     Status:  MEDLINE    
AIMS: To carry out a randomized clinical trial to compare the effect of palmitoylethanolamide (PEA) versus ibuprofen, a nonsteroidal anti-inflammatory drug (NSAID), for pain relief in temporomandibular joint (TMJ) osteoarthritis or arthralgia. PEA acts as an endogenous agent with an autacoid local inflammation antagonism and modulates mast cell behavior controlling both acute and chronic inflammation.
METHODS: A triple-blind randomized clinical trial was conducted on 24 patients (16 women and 8 men) aged 24 to 54 years and suffering from TMJ osteoarthritis or arthralgia. The patients were enrolled from a group of 120 consecutive patients referred to the University of Bologna's Department of Orthodontics. Patients were randomly divided into two groups: group A (12 subjects) received PEA 300 mg in the morning and 600 mg in the evening for 7 days and then 300 mg twice a day for 7 more days. Group B (12 subjects) received ibuprofen 600 mg three times a day for 2 weeks. Every patient recorded the intensity of spontaneous pain on a visual analog scale twice a day. Maximum mouth opening was recorded by a blind operator during the first visit and again after the 14th day of drug treatment. A t test was used for data comparisons.
RESULTS: Pain decrease after 2 weeks of treatment was significantly higher in group A than in group B (P = .0001); maximum mouth opening improved more in group A than in group B (P = .022).
CONCLUSION: These data suggest that PEA is effective in treating TMJ inflammatory pain.
Ida Marini; Maria Lavinia Bartolucci; Francesco Bortolotti; Maria Rosaria Gatto; Giulio Alessandri Bonetti
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Publication Detail:
Type:  Comparative Study; Journal Article; Randomized Controlled Trial    
Journal Detail:
Title:  Journal of orofacial pain     Volume:  26     ISSN:  1064-6655     ISO Abbreviation:  J Orofac Pain     Publication Date:  2012  
Date Detail:
Created Date:  2012-05-04     Completed Date:  2012-06-26     Revised Date:  2014-07-31    
Medline Journal Info:
Nlm Unique ID:  9418507     Medline TA:  J Orofac Pain     Country:  United States    
Other Details:
Languages:  eng     Pagination:  99-104     Citation Subset:  D    
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MeSH Terms
Anti-Inflammatory Agents, Non-Steroidal / administration & dosage,  therapeutic use*
Arthralgia / drug therapy*,  etiology
Double-Blind Method
Ibuprofen / administration & dosage,  therapeutic use
Middle Aged
Osteoarthritis / complications,  drug therapy*
Pain Measurement
Palmitic Acids / administration & dosage,  therapeutic use*
Range of Motion, Articular
Temporomandibular Joint Disorders / complications*,  drug therapy
Young Adult
Reg. No./Substance:
0/Anti-Inflammatory Agents, Non-Steroidal; 0/Endocannabinoids; 0/Ethanolamines; 0/Palmitic Acids; 544-31-0/palmidrol; WK2XYI10QM/Ibuprofen

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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