Document Detail

Palmitic acid metabolism in the soleus muscle in vitro in hypo- and hyperthyroid rats.
MedLine Citation:
PMID:  15133667     Owner:  NLM     Status:  MEDLINE    
The aim of this study was to establish whether the rate of fatty acid (FA) incorporation and its utilization by the isolated soleus muscle is modified under conditions of thyroid hormone deficit or excess. The rate of palmitic acid (PA) uptake, oxidation and incorporation into intramuscular lipids with increasing PA concentration (0.5-1.5 mM) in the incubation medium were determined. In hypothyroid rats intramuscular triacylglycerol (TG) synthesis was increased, while the rate of PA oxidation to CO2 and incorporation into mono- and diacylglycerols (MG/DG) and phospholipids (PL) remained unchanged. In rats with triiodothyronine (T3) excess the rate of all processes studied was enhanced, although the percentage incorporation of PA into different classes of intramuscular lipids was fairly constant and, independently of thyroid state and FA concentration in the medium, was 56-66% for TG, 9-14% for MG/DG and 24-32% for PL. Our results thus indicate that even short-term T3 excess accelerates the rate of FA uptake and metabolism in the oxidative soleus muscle, whereas in hypothyroid rats only intramuscular TG synthesis is affected.
Monika Górecka; Marcin Synak; Józef Langfort; Hanna Kaciuba-Uściłko; Ewa Zernicka
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Publication Detail:
Type:  In Vitro; Journal Article     Date:  2004-05-05
Journal Detail:
Title:  Pflügers Archiv : European journal of physiology     Volume:  448     ISSN:  0031-6768     ISO Abbreviation:  Pflugers Arch.     Publication Date:  2004 Jul 
Date Detail:
Created Date:  2004-06-28     Completed Date:  2005-01-26     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0154720     Medline TA:  Pflugers Arch     Country:  Germany    
Other Details:
Languages:  eng     Pagination:  445-51     Citation Subset:  IM    
Department of Applied Physiology, Medical Research Centre, Polish Academy of Sciences, 5 Pawińskiego St., 02-106, Warsaw, Poland.
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MeSH Terms
Carbon Dioxide / metabolism
Hyperthyroidism / metabolism*
Hypothyroidism / metabolism*
Muscle, Skeletal / metabolism*
Palmitic Acid / pharmacokinetics*
Phospholipids / blood
Rats, Wistar
Triglycerides / blood
Reg. No./Substance:
0/Phospholipids; 0/Triglycerides; 124-38-9/Carbon Dioxide; 57-10-3/Palmitic Acid

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