| Palmitate and oleate metabolism of rainbow trout in vivo. | |
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MedLine Citation:
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PMID: 11818229 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The turnover rates of palmitate and oleate were measured in vivo by continuous infusion of 1-[14C]palmitate and 9,10-[3H]oleate in rainbow trout. Our goals were: (1) to quantify the incorporation of a saturated and of a monounsaturated fatty acid into other classes of plasma lipids (neutral lipids, NL, and phospholipids, PL); and (2) to determine whether they could both be used as tracers to quantify fluxes of total non-esterified fatty acids (NEFA). We found that both acids play very different physiological roles because palmitate is preferentially channeled towards plasma PL, whereas oleate is mainly incorporated in circulating NL. Consequently, palmitate is predominantly involved in membrane PL turnover and oleate in the metabolism of circulating NL that may be used to shuttle oxidative fuel in teleosts. Despite this striking difference in their metabolism, palmitate and oleate have flux rates that are proportional to their relative abundance in plasma NEFA (i.e. they have the same fractional turnover rate). They can therefore both be used as reliable tracers to quantify the kinetics of total NEFA. |
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Authors:
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Jean Michel Weber; Gérard Brichon; Jacques Bodennec; Georges Zwingelstein |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Comparative biochemistry and physiology. Part A, Molecular & integrative physiology Volume: 131 ISSN: 1095-6433 ISO Abbreviation: Comp. Biochem. Physiol., Part A Mol. Integr. Physiol. Publication Date: 2002 Feb |
Date Detail:
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Created Date: 2002-01-30 Completed Date: 2002-05-31 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 9806096 Medline TA: Comp Biochem Physiol A Mol Integr Physiol Country: United States |
Other Details:
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Languages: eng Pagination: 409-16 Citation Subset: IM |
Affiliation:
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Biology Department, University of Ottawa, 30 Marie Curie, Ottawa, Ontario, Canada K1N 6N5. jmweber@science.uottawa.ca |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Animals Carbon Isotopes Fatty Acids / blood, metabolism Fatty Acids, Nonesterified / blood, metabolism Kinetics Oleic Acid / blood, metabolism* Oncorhynchus mykiss / blood, metabolism* Palmitates / blood, metabolism* Phospholipids / blood, metabolism Time Factors |
| Chemical | |
Reg. No./Substance:
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0/Carbon Isotopes; 0/Fatty Acids; 0/Fatty Acids, Nonesterified; 0/Palmitates; 0/Phospholipids; 112-80-1/Oleic Acid |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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