Document Detail


Palmitate and oleate metabolism of rainbow trout in vivo.
MedLine Citation:
PMID:  11818229     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The turnover rates of palmitate and oleate were measured in vivo by continuous infusion of 1-[14C]palmitate and 9,10-[3H]oleate in rainbow trout. Our goals were: (1) to quantify the incorporation of a saturated and of a monounsaturated fatty acid into other classes of plasma lipids (neutral lipids, NL, and phospholipids, PL); and (2) to determine whether they could both be used as tracers to quantify fluxes of total non-esterified fatty acids (NEFA). We found that both acids play very different physiological roles because palmitate is preferentially channeled towards plasma PL, whereas oleate is mainly incorporated in circulating NL. Consequently, palmitate is predominantly involved in membrane PL turnover and oleate in the metabolism of circulating NL that may be used to shuttle oxidative fuel in teleosts. Despite this striking difference in their metabolism, palmitate and oleate have flux rates that are proportional to their relative abundance in plasma NEFA (i.e. they have the same fractional turnover rate). They can therefore both be used as reliable tracers to quantify the kinetics of total NEFA.
Authors:
Jean Michel Weber; Gérard Brichon; Jacques Bodennec; Georges Zwingelstein
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Comparative biochemistry and physiology. Part A, Molecular & integrative physiology     Volume:  131     ISSN:  1095-6433     ISO Abbreviation:  Comp. Biochem. Physiol., Part A Mol. Integr. Physiol.     Publication Date:  2002 Feb 
Date Detail:
Created Date:  2002-01-30     Completed Date:  2002-05-31     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  9806096     Medline TA:  Comp Biochem Physiol A Mol Integr Physiol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  409-16     Citation Subset:  IM    
Affiliation:
Biology Department, University of Ottawa, 30 Marie Curie, Ottawa, Ontario, Canada K1N 6N5. jmweber@science.uottawa.ca
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MeSH Terms
Descriptor/Qualifier:
Animals
Carbon Isotopes
Fatty Acids / blood,  metabolism
Fatty Acids, Nonesterified / blood,  metabolism
Kinetics
Oleic Acid / blood,  metabolism*
Oncorhynchus mykiss / blood,  metabolism*
Palmitates / blood,  metabolism*
Phospholipids / blood,  metabolism
Time Factors
Chemical
Reg. No./Substance:
0/Carbon Isotopes; 0/Fatty Acids; 0/Fatty Acids, Nonesterified; 0/Palmitates; 0/Phospholipids; 112-80-1/Oleic Acid

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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