| Palmar-plantar hyperpigmentation with capecitabine in adjuvant colon cancer. | |
| | |
MedLine Citation:
|
PMID: 19440857 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
BACKGROUND: Capecitabine (XELODA) is a chemotherapeutic agent used widely in the treatment of adjuvant/metastatic colon cancer and metastatic breast cancer. It is usually well tolerated; however, one of the major side effects, hand-foot syndrome (HFS), can be quite disabling. Hyperpigmentation is currently not part of the grading system of HFS, but may be a marker of developing toxicity. CASE REPORT: Here, we describe three patients treated with adjuvant capecitabine for colon cancer (a 49-year-old East Indian man, a 58-year-old Asian woman, and a 54-year-old Aboriginal man) who developed moderate to severe HFS requiring delay and dose reduction. In every case, toxic side effects were preceded by hyperpigmented macules on the hands and feet. CONCLUSION: Hyperpigmentation of the hands and feet is a rare side effect with capecitabine chemotherapy and appeared to predict impending grade 2 HFS in our patients. Clinicians and health care workers in oncology should be aware of this potential side effect; however, further investigation is required to determine whether or not palmar-plantar hyperpigmentation should be included in the spectrum of HFS. Hyperpigmentation may also be more common in the non-Caucasian populations but more research is required to determine the ethnic distribution of this finding. |
| | |
Authors:
|
Michael M Vickers; Jacob C Easaw |
Publication Detail:
|
Type: Case Reports; Journal Article Date: 2009-05-14 |
Journal Detail:
|
Title: Journal of gastrointestinal cancer Volume: 39 ISSN: 1941-6628 ISO Abbreviation: - Publication Date: 2008 |
Date Detail:
|
Created Date: 2009-06-17 Completed Date: 2009-09-08 Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 101479627 Medline TA: J Gastrointest Cancer Country: United States |
Other Details:
|
Languages: eng Pagination: 141-3 Citation Subset: IM |
Affiliation:
|
Department of Medical Oncology, Tom Baker Cancer Center, 1331 29th Street, NW Calgary, Alberta, Canada. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Antimetabolites, Antineoplastic
/
adverse effects Colonic Neoplasms / drug therapy Deoxycytidine / adverse effects, analogs & derivatives* Female Fluorouracil / adverse effects, analogs & derivatives* Foot Dermatoses / chemically induced* Hand Dermatoses / chemically induced* Humans Hyperpigmentation / chemically induced* Male Middle Aged |
| Chemical | |
Reg. No./Substance:
|
0/Antimetabolites, Antineoplastic; 154361-50-9/capecitabine; 51-21-8/Fluorouracil; 951-77-9/Deoxycytidine |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Predicting Non-Sentinel Lymph Node Status After Positive Sentinel Biopsy in Breast Cancer: What Mode...
Next Document: Genetic Insights into Congenital Neutropenia.