Document Detail


Palmar-plantar erythrodysesthesia associated with scrotal and penile involvement with capecitabine.
MedLine Citation:
PMID:  17311704     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Capecitabine is an orally active fluoropyrimidine that has been approved for first-line treatment of metastatic colorectal cancer when fluoropyrimidines alone are indicated. One of the toxicities described in the literature associated with capecitabine is palmar-plantar erythrodysesthesia. Based on a careful review of the literature, no reported cases of erythema, ulceration, and swelling that involves the penis and scrotum have been described in association with capecitabine. The following 2 cases illustrate palmar-plantar erythrodysesthesia with scrotal and penile involvement secondary to capecitabine.
Authors:
Christy M Sapp; Philip DeSimone
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Publication Detail:
Type:  Case Reports; Journal Article    
Journal Detail:
Title:  Clinical colorectal cancer     Volume:  6     ISSN:  1533-0028     ISO Abbreviation:  Clin Colorectal Cancer     Publication Date:  2007 Jan 
Date Detail:
Created Date:  2007-02-21     Completed Date:  2007-04-09     Revised Date:  2013-05-28    
Medline Journal Info:
Nlm Unique ID:  101120693     Medline TA:  Clin Colorectal Cancer     Country:  United States    
Other Details:
Languages:  eng     Pagination:  382-5     Citation Subset:  IM    
Affiliation:
University of Kentucky, Markey Cancer Center, Lexington, KY 40536-0093, USA.
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MeSH Terms
Descriptor/Qualifier:
Aged
Antimetabolites, Antineoplastic / adverse effects*
Colorectal Neoplasms / drug therapy*
Deoxycytidine / adverse effects,  analogs & derivatives*
Erythema / chemically induced*
Fluorouracil / adverse effects,  analogs & derivatives*
Humans
Male
Middle Aged
Penis / drug effects*,  pathology
Scrotum / drug effects*,  pathology
Chemical
Reg. No./Substance:
0/Antimetabolites, Antineoplastic; 51-21-8/Fluorouracil; 6804DJ8Z9U/capecitabine; 951-77-9/Deoxycytidine

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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