Document Detail

Pallidotomy increases activity of motor association cortex in Parkinson's disease: a positron emission tomographic study.
MedLine Citation:
PMID:  7778851     Owner:  NLM     Status:  MEDLINE    
Stereotactic posteroventral pallidotomy can improve motor performance in Parkinson's disease. Interruption of inhibitory pallidal projections to ventrolateral thalamus, components of a cortical-basal ganglia motor loop allows for this clinical benefit. We hypothesized that pallidotomy would lead to increased movement related activity in motor cortical areas receiving projections from ventrolateral thalamus. This was tested in 6 Parkinson's disease patients who underwent stereotactic posteroventral pallidotomy. Each patient was imaged with positron emission tomography (PET) measures of regional cerebral blood flow (rCBF) during performance of a simple prehension task and at rest. Scans were acquired before and 17 weeks after surgery. After pallidotomy, movement-related changes of rCBF increased significantly in both the supplementary motor area (SMA) and premotor cortex but not in primary motor cortex. The results demonstrate the importance of pallidothalamic circuitry for regulating volitional movements and confirm that disruption of inhibitory input to the ventrolateral thalamus can augment movement-related activity in motor association areas.
S T Grafton; C Waters; J Sutton; M F Lew; W Couldwell
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Annals of neurology     Volume:  37     ISSN:  0364-5134     ISO Abbreviation:  Ann. Neurol.     Publication Date:  1995 Jun 
Date Detail:
Created Date:  1995-07-07     Completed Date:  1995-07-07     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  7707449     Medline TA:  Ann Neurol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  776-83     Citation Subset:  IM    
Department of Neurology, University of Southern California, Los Angeles 90033-4606, USA.
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MeSH Terms
Globus Pallidus / surgery*
Middle Aged
Motor Cortex / physiopathology*,  radionuclide imaging
Parkinson Disease / physiopathology*,  radionuclide imaging,  surgery*
Tomography, Emission-Computed
Grant Support

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