Document Detail


Pallidal stimulation: effect of pattern and rate on bradykinesia in the non-human primate model of Parkinson's disease.
MedLine Citation:
PMID:  21767534     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Deep brain stimulation (DBS) involves the delivery of continuous, fixed-frequency electrical pulses to specific brain regions; however the reliance of therapeutic benefit on the fixed-frequency nature of the stimulation pattern is currently unknown. To address this, we investigated the effect of changes in the pattern and frequency of DBS in the internal segment of the globus pallidus (GPi) on bradykinesia in a single, hemi-parkinsonian monkey. Therapeutic parameters (i.e., contacts, pulse width, amplitude) were established for fixed-frequency stimulation at 135 Hz based on improved movement times during a reach and retrieval task. Thereafter, the pattern and frequency of stimulation were varied to assess the effect of variability, bursting and oscillatory patterns of stimulation on bradykinesia. During fixed-frequency stimulation, performance improved as a function of increasing pulse rate (P<0.01). Using a temporally irregular pattern at the same average frequency failed to alter therapeutic benefit relative to the fixed-frequency condition. Introducing an 80 Hz burst pattern (20 bursts/s at 4 pulses/burst) improved bradykinesia (P<0.01) relative to both "OFF" and 80 Hz fixed-frequency conditions, yielding results comparable to fixed-frequency stimulation at 135 Hz with 40% less current drain. Compared to burst and fixed-frequency stimulations, oscillatory patterns at 4 and 8 Hz were less effective. These results suggest that lower frequency stimulation delivered in a regular bursting pattern may be equally effective and require lower energy than higher frequency continuous patterns of stimulation, thereby prolonging battery life and call into question the role of bursting activity in the pathogenesis of bradykinesia.
Authors:
Kenneth B Baker; Jianyu Zhang; Jerrold L Vitek
Related Documents :
12828904 - Sampling rate effects on surface emg timing and amplitude measures.
1753294 - Effects of low-frequency stimulation on the tension-frequency relations of fast-twitch ...
3760934 - High-frequency oscillations in human electromyograms during voluntary contractions.
17520244 - Periodic increases in force during sustained contraction reduce fatigue and facilitate ...
10875384 - Integration of monaural and binaural evidence of vowel formants.
23550364 - Features of the human rod bipolar cell erg response during fusion of scotopic flicker.
Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural     Date:  2011-07-01
Journal Detail:
Title:  Experimental neurology     Volume:  231     ISSN:  1090-2430     ISO Abbreviation:  Exp. Neurol.     Publication Date:  2011 Oct 
Date Detail:
Created Date:  2011-09-12     Completed Date:  2011-11-02     Revised Date:  2014-09-22    
Medline Journal Info:
Nlm Unique ID:  0370712     Medline TA:  Exp Neurol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  309-13     Citation Subset:  IM    
Copyright Information:
Copyright © 2011 Elsevier Inc. All rights reserved.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:
Animals
Deep Brain Stimulation / methods*
Globus Pallidus / physiopathology*
Hypokinesia / physiopathology,  therapy*
Macaca mulatta
Neurons / physiology
Parkinson Disease, Secondary / physiopathology,  therapy*
Grant Support
ID/Acronym/Agency:
NS037019/NS/NINDS NIH HHS; R01 NS037019/NS/NINDS NIH HHS; R01 NS037019-12/NS/NINDS NIH HHS; RC1 NS068231/NS/NINDS NIH HHS; RC1 NS068231-02/NS/NINDS NIH HHS
Comments/Corrections

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Retinal flavoprotein fluorescence correlates with mitochondrial stress, apoptosis, and chemokine exp...
Next Document:  Construction of a cDNA library from female adult of Toxocara canis, and analysis of EST and immune-r...