Document Detail

Pallidal stimulation: effect of pattern and rate on bradykinesia in the non-human primate model of Parkinson's disease.
MedLine Citation:
PMID:  21767534     Owner:  NLM     Status:  MEDLINE    
Deep brain stimulation (DBS) involves the delivery of continuous, fixed-frequency electrical pulses to specific brain regions; however the reliance of therapeutic benefit on the fixed-frequency nature of the stimulation pattern is currently unknown. To address this, we investigated the effect of changes in the pattern and frequency of DBS in the internal segment of the globus pallidus (GPi) on bradykinesia in a single, hemi-parkinsonian monkey. Therapeutic parameters (i.e., contacts, pulse width, amplitude) were established for fixed-frequency stimulation at 135 Hz based on improved movement times during a reach and retrieval task. Thereafter, the pattern and frequency of stimulation were varied to assess the effect of variability, bursting and oscillatory patterns of stimulation on bradykinesia. During fixed-frequency stimulation, performance improved as a function of increasing pulse rate (P<0.01). Using a temporally irregular pattern at the same average frequency failed to alter therapeutic benefit relative to the fixed-frequency condition. Introducing an 80 Hz burst pattern (20 bursts/s at 4 pulses/burst) improved bradykinesia (P<0.01) relative to both "OFF" and 80 Hz fixed-frequency conditions, yielding results comparable to fixed-frequency stimulation at 135 Hz with 40% less current drain. Compared to burst and fixed-frequency stimulations, oscillatory patterns at 4 and 8 Hz were less effective. These results suggest that lower frequency stimulation delivered in a regular bursting pattern may be equally effective and require lower energy than higher frequency continuous patterns of stimulation, thereby prolonging battery life and call into question the role of bursting activity in the pathogenesis of bradykinesia.
Kenneth B Baker; Jianyu Zhang; Jerrold L Vitek
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural     Date:  2011-07-01
Journal Detail:
Title:  Experimental neurology     Volume:  231     ISSN:  1090-2430     ISO Abbreviation:  Exp. Neurol.     Publication Date:  2011 Oct 
Date Detail:
Created Date:  2011-09-12     Completed Date:  2011-11-02     Revised Date:  2014-09-22    
Medline Journal Info:
Nlm Unique ID:  0370712     Medline TA:  Exp Neurol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  309-13     Citation Subset:  IM    
Copyright Information:
Copyright © 2011 Elsevier Inc. All rights reserved.
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MeSH Terms
Deep Brain Stimulation / methods*
Globus Pallidus / physiopathology*
Hypokinesia / physiopathology,  therapy*
Macaca mulatta
Neurons / physiology
Parkinson Disease, Secondary / physiopathology,  therapy*
Grant Support

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