Document Detail


Pallidal index on MRI as a target organ dose of manganese: structural equation model analysis.
MedLine Citation:
PMID:  15935207     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
We have used a structural equation model (SEM) to analyze the interrelationships among exposure markers, magnetic resonance imaging (MRI) signal index, and neurobehavioral effects. Based on exposure groups, we assessed blood manganese, MRI measurements of pallidal index (PI), and neurobehavioral core test battery (WHO-NCTB) on 111 male workers occupationally exposed to manganese, including welders, smelter workers, and welding rod manufacturing workers. Latent variables were constructed to represent the neurobehavioral effects in an integrated way. The structural equation model revealed that airborne manganese and blood manganese contribute to PI significantly. Manganese exposure in the ambient air may lead to an increase in the internal dose, not only indirectly, by increasing blood manganese level, but also directly, independent of blood concentration. PI significantly contributed to a decrease in neurobehavioral test scores. We found that airborne manganese contributed to PI, and that PI is the most effective predictor of neurobehavioral performance, after adjusting for age and level of education. In conclusion, PI on MRI reflects target organ dose of occupational manganese exposure.
Authors:
Euna Kim; Yangho Kim; Hae-Kwan Cheong; Sungil Cho; Yong Chul Shin; Joon Sakong; Kyoo Sang Kim; Jung Sun Yang; Young-Woo Jin; Seong-Kyu Kang
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Publication Detail:
Type:  Clinical Trial; Journal Article    
Journal Detail:
Title:  Neurotoxicology     Volume:  26     ISSN:  0161-813X     ISO Abbreviation:  Neurotoxicology     Publication Date:  2005 Jun 
Date Detail:
Created Date:  2005-06-06     Completed Date:  2005-08-12     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  7905589     Medline TA:  Neurotoxicology     Country:  Netherlands    
Other Details:
Languages:  eng     Pagination:  351-9     Citation Subset:  IM    
Affiliation:
Occupational Safety and Health Research Institute, Korea Occupational Safety and Health Agency, Incheon, Republic of Korea.
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MeSH Terms
Descriptor/Qualifier:
Accidents, Occupational / statistics & numerical data
Adult
Affect / drug effects
Attention / drug effects
Behavior / drug effects
Cross-Sectional Studies
Globus Pallidus / pathology*
Humans
Inhalation Exposure
Magnetic Resonance Imaging
Male
Manganese / analysis,  blood
Manganese Poisoning / pathology*,  psychology
Memory / drug effects
Middle Aged
Neuropsychological Tests
Occupational Exposure / adverse effects*
Psychomotor Performance / drug effects
Regression Analysis
Socioeconomic Factors
Chemical
Reg. No./Substance:
7439-96-5/Manganese

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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